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Elizabeth A Wellberg et al.
Breast cancer research : BCR, 16(6), 481-481 (2014-12-05)
Spot14 (S14), encoded by the THRSP gene, regulates de novo fatty acid synthesis in the liver, adipose, and lactating mammary gland. We recently showed that S14 stimulated fatty acid synthase (FASN) activity in vitro, and increased the synthesis of fatty
Anna K Coussens et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(26), 8052-8057 (2015-06-17)
Cape Town, South Africa, has a seasonal pattern of UVB radiation and a predominantly dark-skinned urban population who suffer high HIV-1 prevalence. This coexistent environmental and phenotypic scenario puts residents at risk for vitamin D deficiency, which may potentiate HIV-1
Michael K Tian et al.
The European journal of neuroscience, 40(4), 2608-2618 (2014-05-16)
Cholinergic stimulation of the cerebral cortex is essential for tasks requiring attention; however, there is still some debate over which cortical regions are required for such tasks. There is extensive cholinergic innervation of both primary and associative cortices, and transient
Alfonso Pastor-Clerigues et al.
PloS one, 9(12), e115404-e115404 (2014-12-17)
Home parenteral nutrition (PN) is associated with many complications including severe hepatobiliary dysfunction. Commercial ω-6 fatty acid-soybean based-lipid emulsions in PN may mediate long term PN associate liver disease (PNALD) whereas ω-3-fish oil parenteral emulsions have shown to reverse PNALD
Rongsheng Su et al.
Biological trace element research, 167(1), 110-114 (2015-03-13)
The aim of this study was to explore the effects of selenium addition on hepatic tissue ultrastructure and mitochondrial antioxidant capacity in copper-overloaded rats. Eighteen adult male Sprague-Dawley (SD) rats were randomly divided into three groups (n = 6 per group). Each
Verona Villar-Cerviño et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(23), 8718-8729 (2015-06-13)
In the developing telencephalon, the medial ganglionic eminence (MGE) generates many cortical and virtually all striatal interneurons. While the molecular mechanisms controlling the migration of interneurons to the cortex have been extensively studied, very little is known about the nature
Larry Gray et al.
Pediatrics, 135(3), e607-e614 (2015-02-18)
Increasing data suggest that neonatal pain has long-term consequences. Nonpharmacologic techniques (sucrose taste, pacifier suckling, breastfeeding) are effective and now widely used to combat minor neonatal pain. This study examined the analgesic effect of sucrose combined with radiant warmth compared
Vibe Bach et al.
Journal of agricultural and food chemistry, 63(44), 9803-9811 (2015-10-30)
The eating quality of carrots (Daucus carota L.) was investigated to evaluate the impact of cropping systems (one conventional and three organic systems) and growing years (2007, 2008, and 2009) on root size, chemical composition, and sensory quality. The content
Caterina Holz et al.
Probiotics and antimicrobial proteins, 7(2), 91-100 (2014-12-08)
Reducing the amount of Helicobacter pylori in the stomach by selective bacterial-bacterial cell interaction was sought as an effective and novel method for combating the stomach pathogen. Lactobacillus reuteri DSM17648 was identified as a highly specific binding antagonist to H.
Sona Balentova et al.
Neurochemical research, 40(3), 501-513 (2014-12-10)
Ionizing radiation induces altered brain tissue homeostasis and can lead to morphological and functional deficits. In this study, adult male Wistar rats received whole-body exposure with fractionated doses of gamma rays (a total dose of 5 Gy) and were investigated
Sung-Chul Lim et al.
Oncology reports, 34(3), 1261-1268 (2015-07-03)
Carcinoma cells that have acquired drug resistance often exhibit cross-resistance to various other cytotoxic stimuli. Here, we investigated the effects of ursodeoxycholic acid (UDCA), a gastrointestinal tumor-suppressor, on a cisplatin‑resistant SNU601 gastric cancer subline (SNU601/R). While other anticancer drugs, including
Chrisovalantis Papadopoulos et al.
PLoS genetics, 11(4), e1005149-e1005149 (2015-04-16)
Mutations in SPAST, encoding spastin, are the most common cause of autosomal dominant hereditary spastic paraplegia (HSP). HSP is characterized by weakness and spasticity of the lower limbs, owing to progressive retrograde degeneration of the long corticospinal axons. Spastin is
Marcin Jabłoński et al.
Psychiatria Danubina, 25(4), 371-378 (2013-11-20)
The aim of the study was to determine the influence of DRD2 gene polymorphisms in exon 8 G/A (rs 6276) in the promoter region -141 C Ins/Del (rs1799732) and the influence of ANKK-1 gene Taq-1A polymorphism (rs 1800497) on the
Tess S Weathers et al.
Environmental science & technology, 49(9), 5458-5466 (2015-03-26)
This study focuses on interactions between aerobic soil-derived hydrocarbon degrading bacteria and a suite of perfluorocarboxylic acids and perfluoroalkylsulfonates that are found in aqueous film-forming foams used for fire suppression. No effect on toluene degradation rate or induction time was
Ashutosh Rastogi et al.
Behavioural brain research, 296, 233-239 (2015-09-20)
Present study investigated seasonal plasticity in neural activity of the olfactory system, and assessed whether this was influenced by differences in seasonal life-history states (LHSs) between the non-migratory and migratory birds. Brains of non-migratory Indian weaver birds and migratory redheaded
L Dumont et al.
Andrology, 3(3), 611-625 (2015-05-28)
Testicular tissue cryopreservation offers the hope of preserved future fertility to pre-pubertal boys with cancer before exposition to gonadotoxic treatments. The objective of this study was to compare controlled slow freezing (CSF) with five vitrification techniques for cryopreservation of murine
Sameh K Wasseff et al.
Neurobiology of disease, 82, 86-98 (2015-06-09)
Oligodendrocyte:oligodendrocyte (O:O) gap junction (GJ) coupling is a widespread and essential feature of the CNS, and is mediated by connexin47 (Cx47) and Cx32. Loss of function mutations affecting Cx47 results in a severe leukodystrophy, Pelizeus-Merzbacher-like disease (also known as Hypomyelinating
Takuma Yoshizumi et al.
Nature communications, 5, 4713-4713 (2014-08-21)
Mitochondria contribute to cellular innate immunity against RNA viruses. Mitochondrial-mediated innate immunity is regulated by signalling molecules that are recruited to the mitochondrial membrane, and depends on the mitochondrial inner membrane potential (Δψm). Here we examine the physiological relevance of
V Matafora et al.
Molecular bioSystems, 11(6), 1543-1551 (2015-02-11)
Fabry disease (FD) is an X-linked lysosomal storage disorder caused by a deficiency of the lysosomal hydrolase α-galactosidase A (α-GalA) that leads to the intra-lysosomal accumulation of globotriaosylceramide (Gb3) in various organ systems. As a consequence, a multisystems disorder develops
Mir-Jamal Hosseini et al.
Cell biochemistry and biophysics, 70(1), 367-381 (2014-04-03)
Oxidative damage has been implicated in disorders associated with abnormal copper metabolism and also Cu(2+) overloading states. Besides, mitochondria are one of the most important targets for Cu(2+), an essential redox transition metal, induced hepatotoxicity. In this study, we aimed
Nan Hu et al.
Pharmacological research, 100, 175-189 (2015-08-16)
Second hand smoke is an independent risk factor for cardiovascular disease. Adiponectin (APN), an adipose-derived adipokine, has been shown to offer cardioprotective effect through an AMPK-dependent manner. This study was designed to evaluate the impact of adiponectin deficiency on second
M Yue et al.
Neurobiology of disease, 78, 172-195 (2015-04-04)
Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully determined but evidence points towards LRRK2 mutations causing a gain in kinase
Chun-Nun Chao et al.
Journal of translational medicine, 13, 29-29 (2015-01-28)
Diffuse large B-cell lymphoma (DLBCL) is one of the most common types of aggressive B-cell non-Hodgkin lymphoma. About one-third of patients are either refractory to the treatment or experience relapse afterwards, pointing to the necessity of developing other effective therapies
Christian K Pfaller et al.
Journal of virology, 89(15), 7735-7747 (2015-05-15)
Defective interfering RNAs (DI-RNAs) of the viral genome can form during infections of negative-strand RNA viruses and outgrow full-length viral genomes, thereby modulating the severity and duration of infection. Here we document the frequent de novo generation of copy-back DI-RNAs
R Huang et al.
Applied and environmental microbiology, 80(23), 7212-7218 (2014-09-14)
Streptococcus gordonii is a commensal species of human oral flora. It initiates dental biofilm formation and provides binding sites for later colonizers to attach to and generate mature biofilm. Smoking is the second highest risk factor for periodontal disease, and
Moinecha Madi et al.
The Journal of membrane biology, 248(5), 903-908 (2015-03-20)
DNA electrotransfer is a successful technic for gene delivery. However, its use in clinical applications is limited since little is known about the mechanisms governing DNA electrotransfer in the complex environment occurring in a tissue. The objectives of this work
Hemant Kumar Rawat et al.
Antonie van Leeuwenhoek, 107(3), 799-811 (2015-01-07)
Owing to applications in the food and nutraceutical industries, inulinases, fructosyltransferases and sucrases have gained considerable attention in recent times. Twenty-five fungal strains were screened for production of these enzymes on three different media formulated using inulin-rich plant extracts prepared
Luiz G Maturana et al.
Brain and behavior, 3(4), 417-430 (2014-01-02)
The purpose of this study was to investigate the influence of implanting collagen with a supramolecular organization on peripheral nerve regeneration, using the sciatic nerve tubulization technique. For this purpose, adult female Sprague Dawley rats were divided into five groups:
Esak Lee et al.
Nature communications, 5, 4715-4715 (2014-09-03)
Breast cancer metastasis involves lymphatic dissemination in addition to hematogenous spreading. Although stromal lymphatic vessels (LVs) serve as initial metastatic routes, roles of organ-residing LVs are underinvestigated. Here we show that lymphatic endothelial cells (LECs), a component of LVs within
Sheng-Hui Yang et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 185(6), 677-693 (2015-06-03)
There are essentially four different morphological types of pseudobranchs in teleosts, including lamellae-free, lamellae semi-free, covered, and embedded types. In the euryhaline silver moony (Monodactylus argenteus), the pseudobranch belongs to the lamellae semi-free type, which is characterized by one row
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