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Michael R McAllaster et al.
Molecular biology of the cell, 26(17), 3013-3029 (2015-07-03)
Trypanosoma brucei is the causative agent of African sleeping sickness, a devastating disease endemic to sub-Saharan Africa with few effective treatment options. The parasite is highly polarized, including a single flagellum that is nucleated at the posterior of the cell
Dennis Boye Larsen et al.
Journal of receptor and signal transduction research, 34(4), 261-269 (2014-02-06)
Previous studies have demonstrated that various subtypes of the metabotropic glutamate receptors (mGluRs) are expressed in the dorsal root ganglion (DRG) of the peripheral nervous system (PNS), implicating that glutamate potentially contributes to sensory transmission through these receptors. While mGluR
Anirban Baral et al.
The Plant cell, 27(4), 1297-1315 (2015-04-23)
Endocytosis is a ubiquitous cellular process that is characterized well in animal cells in culture but poorly across intact, functioning tissue. Here, we analyze endocytosis throughout the Arabidopsis thaliana root using three classes of probes: a lipophilic dye, tagged transmembrane
Elyse K Hanly et al.
Oncotarget, 6(37), 39702-39713 (2015-08-19)
Treatment options for advanced metastatic thyroid cancer patients are limited. Vemurafenib, a BRAFV600E inhibitor, has shown promise in clinical trials although cellular resistance occurs. Combination therapy that includes BRAFV600E inhibition and avoids resistance is a clinical need. We used an
Mattias S Dahllöf et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 35(1), 63-70 (2014-07-26)
Histone deacetylase (HDAC) inhibition protects pancreatic beta-cells against apoptosis induced by the combination of the proinflammatory cytokines interleukin (IL)-1β and interferon (IFN)-γ. Decreased expression of cell damage-related genes is observed on the transcriptional level upon HDAC inhibition using either IL-1β
Helena Bros et al.
Traffic (Copenhagen, Denmark), 16(8), 906-917 (2015-04-24)
Owing to the small size of mitochondria and the complexity of their motility patterns, mitochondrial tracking is technically challenging. Mitochondria are often tracked manually; however, this is time-consuming and prone to measurement error. Here, we examined the suitability of four
Emanuela Pannia et al.
Behavioural brain research, 278, 1-11 (2014-09-30)
High multivitamin (10-fold, HV) and high folic acid (Fol) diets fed to pregnant Wistar rats increase body weight and characteristics of the metabolic syndrome in their offspring. Our objective was to determine the effects of a HV maternal diet on
David Rhys Thomas et al.
Plant cell reports, 33(11), 1801-1814 (2014-07-23)
The yield of recombinant hEGF was increased approximately tenfold through a range of optimisations. Further, the recombinant protein was found to have biological activity comparable to commercial hEGF. Human epidermal growth factor (hEGF) is a powerful mitogen that can enhance
Salt-Tolerant Superoleophobicity on Alginate Gel Surfaces Inspired by Seaweed (Saccharina japonica).
Yue Cai et al.
Advanced materials (Deerfield Beach, Fla.), 27(28), 4162-4168 (2015-06-23)
Margherita Eufemi et al.
Neurochemistry international, 81, 48-56 (2015-01-31)
Microglia are macrophages within the central nervous system playing a central role in neurodegenerative disorders. Although the initial engagement of microglia seems to be neuroprotective, many lines of evidence indicate that its persistent activation contributes to dismantle neuronal activity and
Marta Librán-Pérez et al.
The Journal of experimental biology, 218(Pt 16), 2610-2619 (2015-06-20)
Using rainbow trout fed with low-fat or high-fat diets, we aimed to determine whether the response of food intake, mRNA abundance of hypothalamic neuropeptides involved in the metabolic regulation of food intake and fatty acid sensing systems in the hypothalamus
Eman Y Gohar et al.
PloS one, 9(4), e95079-e95079 (2014-04-16)
We investigated the effect of chronic nicotine on cholinergically-mediated renal vasodilations in female rats and its modulation by the nitric oxide synthase (NOS)/heme oxygenase (HO) pathways. Dose-vasodilatory response curves of acetylcholine (0.01-2.43 nmol) were established in isolated phenylephrine-preconstricted perfused kidneys
Muhammad Amir Yunus et al.
Journal of virology, 89(2), 1218-1229 (2014-11-14)
All members of the Caliciviridae family of viruses produce a subgenomic RNA during infection. The subgenomic RNA typically encodes only the major and minor capsid proteins, but in murine norovirus (MNV), the subgenomic RNA also encodes the VF1 protein, which
Chuang Wang et al.
Metabolic brain disease, 29(3), 673-682 (2014-04-08)
Inhibition of phosphodiesterase-4 or 5 (PDE4 or PDE5) increases cyclic adenosine monophosphate (cAMP)- or cyclic guanosine monophosphate (cGMP), respectively, which activates cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF)/neuropeptide VGF (non-acryonimic) signaling and produces antidepressant-like effects on behavior. However, causal
Troy J Pereira et al.
The Journal of physiology, 593(14), 3181-3197 (2015-04-30)
Maternal obesity is associated with a high risk for gestational diabetes mellitus (GDM), which is a common complication of pregnancy. The influence of maternal obesity and GDM on the metabolic health of the offspring is poorly understood. We hypothesize that
Adam D Bachstetter et al.
Journal of neuroinflammation, 11, 175-175 (2014-10-10)
The p38α mitogen-activated protein kinase (MAPK) is a well-characterized intracellular kinase involved in the overproduction of proinflammatory cytokines from glia. As such, p38α appears to be a promising therapeutic target for neurodegenerative diseases associated with neuroinflammation. However, the in vivo
Taiji Hamada et al.
Oncotarget, 5(15), 6076-6086 (2014-08-26)
The PCP4/PEP19 is a calmodulin-binding anti-apoptotic peptide in neural cells but its potential role in human cancer has largely been unknown. We investigated the expression of PCP4/PEP19 in human breast cancer cell lines MCF-7, SK-BR-3, and MDA-MB-231 cells, and found
Rainer Schreiber et al.
Pflugers Archiv : European journal of physiology, 467(6), 1203-1213 (2014-07-01)
Intestinal epithelial electrolyte secretion is activated by increase in intracellular cAMP or Ca(2+) and opening of apical Cl(-) channels. In infants and young animals, but not in adults, Ca(2+)-activated chloride channels may cause secretory diarrhea during rotavirus infection. While detailed
Qian Zhang et al.
Journal of translational medicine, 13, 177-177 (2015-06-05)
Recent experimental and clinical studies have indicated the cardioprotective role of sildenafil during ischemia/reperfusion (I/R) injury. Sildenafil has been shown to attenuate postresuscitation myocardial dysfunction in piget models of ventricular fibrillation. This study was designed to investigate if administration of
Anna Rubinski et al.
PLoS computational biology, 11(11), e1004632-e1004632 (2015-11-26)
Glutamatergic synapse size remodeling is governed not only by specific activity forms but also by apparently stochastic processes with well-defined statistics. These spontaneous remodeling processes can give rise to skewed and stable synaptic size distributions, underlie scaling of these distributions
Robert Hooper et al.
Molecular and cellular biology, 35(16), 2790-2798 (2015-06-10)
The incidence of malignant melanoma, a cancer of the melanocyte cell lineage, has nearly doubled in the past 20 years. Wnt5A, akey driver of melanoma invasiveness, induces Ca2 signals. To understand how store-operated calcium entry (SOCE) contributes to Wnt5A-induced malignancy
Michitaka Suzuki et al.
Molecular biology of the cell, 26(12), 2333-2342 (2015-04-24)
Adipocyte triglyceride lipase (ATGL) is the major enzyme involved in the hydrolysis of triglycerides. The Arf1-coat protein complex I (COPI) machinery is known to be engaged in the recruitment of ATGL to lipid droplets (LDs), but the regulatory mechanism has
Lucas Willmann et al.
Scientific reports, 5, 13374-13374 (2015-08-22)
Cancer cells show characteristic effects on cellular turnover and DNA/RNA modifications leading to elevated levels of excreted modified nucleosides. We investigated the molecular signature of different subtypes of breast cancer cell lines and the breast epithelial cell line MCF-10A. Prepurification
Tonya Kueck et al.
PLoS pathogens, 11(8), e1005141-e1005141 (2015-09-01)
HIV-1 Vpu prevents incorporation of tetherin (BST2/ CD317) into budding virions and targets it for ESCRT-dependent endosomal degradation via a clathrin-dependent process. This requires a variant acidic dileucine-sorting motif (ExxxLV) in Vpu. Structural studies demonstrate that recombinant Vpu/tetherin fusions can
Chul-Kyu Park
Mediators of inflammation, 2015, 275126-275126 (2015-12-01)
In the trigeminal system, disruption of acute resolution processing may lead to uncontrolled inflammation and chronic pain associated with the temporomandibular joint (TMJ). Currently, there are no effective treatments for TMJ pain. Recently, it has been recognized that maresin 1
Huazhen Li et al.
Journal of colloid and interface science, 462, 56-63 (2015-10-05)
Stimuli-responsive protein surfactants promise alternative foaming materials that can be made from renewable sources. However, the cost of protein surfactants is still higher than their chemical counterparts. In order to reduce the required amount of protein surfactant for foaming, we
Irina S Babina et al.
Breast cancer research : BCR, 16(1), R19-R19 (2014-02-12)
Most breast cancer-related deaths result from metastasis, a process involving dynamic regulation of tumour cell adhesion and migration. The adhesion protein CD44, a key regulator of cell migration, is enriched in cholesterol-enriched membrane microdomains termed lipid rafts. We recently reported
Jacob Stewart et al.
Environmental toxicology and chemistry, 34(9), 2116-2125 (2015-04-29)
Exposure to nanoparticles (NPs) that release metals with potential phytotoxicity could pose problems in agriculture. The authors of the present study used growth in a model growth matrix, sand, to examine the influence of 5 mmol/kg of Na, K, or Ca
Susumu Takeuchi et al.
Journal of pharmaceutical sciences, 103(11), 3416-3422 (2014-09-25)
In vitro dissolution tests are performed for new formulations to evaluate in vivo performance, which is affected by the change of gastrointestinal (GI) physiology, in the GI tract. Thus, those environmental changes should be introduced to an in vitro dissolution
Fabio Gsaller et al.
The EMBO journal, 33(19), 2261-2276 (2014-08-06)
Balance of physiological levels of iron is essential for every organism. In Aspergillus fumigatus and other fungal pathogens, the transcription factor HapX mediates adaptation to iron limitation and consequently virulence by repressing iron consumption and activating iron uptake. Here, we
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