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Caroline Boudousquié et al.
Journal of immunology (Baltimore, Md. : 1950), 193(6), 2784-2791 (2014-08-17)
Protection against reinfection is mediated by Ag-specific memory CD8 T cells, which display stem cell-like function. Because canonical Wnt (Wingless/Int1) signals critically regulate renewal versus differentiation of adult stem cells, we evaluated Wnt signal transduction in CD8 T cells during
Leonard C Edelstein et al.
Blood, 124(23), 3450-3458 (2014-10-09)
Human platelets express 2 thrombin receptors: protease-activated receptor (PAR)-1 and PAR4. Recently, we reported 3.7-fold increased PAR4-mediated aggregation kinetics in platelets from black subjects compared with white subjects. We now show that platelets from blacks (n = 70) express 14%
Y M Patel et al.
Journal of thrombosis and haemostasis : JTH, 12(5), 716-725 (2014-03-13)
The study of patients with bleeding problems is a powerful approach in determining the function and regulation of important proteins in human platelets. We have identified a patient with a chronic bleeding disorder expressing a homozygous P2RY(12) mutation, predicting an
Use of fluorescein isothiocyanate-dextran to measure proton pumping in lysosomes and related organelles.
S Ohkuma
Methods in enzymology, 174, 131-154 (1989-01-01)
Darshini Kuruppu et al.
Cancer research, 74(15), 4111-4121 (2014-05-31)
Viral oncolysis, the destruction of cancer cells by replicating virus, is an experimental cancer therapy that continues to be explored. The treatment paradigm for this therapy involves successive waves of lytic replication in cancer cells. At present, monitoring viral titer
Yuhua Wang et al.
Antioxidants & redox signaling, 21(16), 2177-2191 (2014-05-03)
This study is designed to assess the protective cardiac effects after myocardial infarction (MI) of (i) cardiovascular progenitor cells (PC) differentiated directly into cardiomyocytes (CM) and endothelial cells (ECs) at the injury site, as separable from the effects of (ii)
Lan Zhang et al.
PloS one, 9(5), e97824-e97824 (2014-05-20)
Adiponectin is an adipokine that sensitizes the body to insulin. Low levels of adiponectin have been reported in obesity, diabetes and periodontitis. In this study we established experimental periodontitis in male adiponectin knockout and diet-induced obesity mice, a model of
Stefanie Steiner et al.
Archivum immunologiae et therapiae experimentalis, 63(1), 53-63 (2014-08-27)
Crohn's disease (CD) and ulcerative colitis (UC) are the two major forms of inflammatory bowel diseases (IBD), which are defined as relapsing inflammations of the gastrointestinal tract. Cyclosporine A (CsA) is a potential rescue treatment to avoid colectomy in severe
Cui Li et al.
Investigative ophthalmology & visual science, 55(10), 6886-6900 (2014-10-10)
To determine if IL-17 regulates Mer tyrosine kinase-positive (MerTK+) cells in Pseudomonas aeruginosa keratitis. Interleukin 17 was tested in normal and infected cornea of susceptible C57BL/6 and resistant BALB/c mice. The latter were treated with recombinant mouse (rm) IL-17; both
Khushwant S Bhullar et al.
Food chemistry, 168, 595-605 (2014-08-31)
Partridgeberry (Vaccinium vitis-idaea) is a polyphenol-rich berry of the Ericaceous family, grown in Newfoundland and Labrador province of Canada. The aims of this study were to identify extraction solvents for the maximum recovery of polyphenols, to establish fractionation technique for
Darshan Sapkota et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(39), E4086-E4095 (2014-09-18)
Previously, we have shown that Onecut1 (Oc1) and Onecut2 (Oc2) are expressed in retinal progenitor cells, developing retinal ganglion cells (RGCs), and horizontal cells (HCs). However, in Oc1-null mice, we only observed an 80% reduction in HCs, but no defects
Marcela Valdés-Tovar et al.
Chronobiology international, 32(2), 164-177 (2014-09-24)
The light-dark cycle is an environmental factor that influences immune physiology, and so, variations of the photoperiod length result in altered immune responsivity. Macrophage physiology comprises a spectrum of functions that goes from host defense to immune down-regulation, in addition
Bei-Bei Cao et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 10(1), 162-178 (2015-02-05)
We previously have shown that cerebellar fastigial nucleus (FN) modulates immune function, but pathways or mechanisms underlying this immunomodulation require clarification. Herein, an anterograde and retrograde tracing of nerve tracts between the cerebellar FN and hypothalamus/thalamus was performed in rats.
Sailesh Palikhe et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 113(3), 276-281 (2014-07-20)
Platelets are actively involved in immune inflammatory processes that release inflammatory mediators. Platelet activation has been reported in various inflammatory diseases; however, few studies have described platelet involvement in chronic urticaria (CU). To investigate platelet-activation markers, namely P2Y12 receptor and
Mizuha Sakashita et al.
Bioorganic & medicinal chemistry, 22(19), 5212-5219 (2014-08-27)
Highly efficient drug carriers targeting hepatocyte is needed for treatment for liver diseases such as liver cirrhosis and virus infections. Galactose or N-acetylgalactosamine is known to be recognized and incorporated into the cells through asialoglycoprotein receptor (ASGPR) that is exclusively
Li Wang et al.
Experimental eye research, 127, 117-123 (2014-07-27)
Choroidal neovascularization (CNV) occurs as a result of age-related macular degeneration (AMD) and causes severe vision loss among elderly patients. High expression of tissue factor (TF) was found in the retinas of AMD patients. In this study, we used anti-TF
Hiroshi Horibe et al.
PloS one, 9(5), e98553-e98553 (2014-05-30)
Insights into the understanding of the influence of the age of MSCs on their cellular responses and regenerative potential are critical for stem cell therapy in the clinic. We have isolated dental pulp stem cells (DPSCs) subsets based on their
S K Rao et al.
Journal of cataract and refractive surgery, 27(3), 432-436 (2001-03-20)
To evaluate the occurrence of cystoid macular edema (CME) after lens extraction, anterior vitrectomy, and intraocular lens implantation (IOL) in children using angioscopy after administration of oral fluorescein. Centers in Tamil Nadu, India, and Hong Kong, China. This study comprised
Evelyn Hartung et al.
Journal of immunology (Baltimore, Md. : 1950), 194(3), 1069-1079 (2014-12-19)
Current subunit vaccines are incapable of inducing Ag-specific CD8(+) T cell cytotoxicity needed for the defense of certain infections and for therapy of neoplastic diseases. In experimental vaccines, cytotoxic responses can be elicited by targeting of Ag into cross-presenting dendritic
Yukiko Kanno et al.
International journal of urology : official journal of the Japanese Urological Association, 21(7), 714-718 (2014-03-05)
To investigate the contribution of bone marrow-derived mesenchymal stem cells to the changes in bladder morphology in response to partial bladder outlet obstruction. Allogenic bone marrow cells were transplanted from transgenic rats expressing green fluorescent protein into female Sprague-Dawley rats
Meghan Larin et al.
Nucleic acids research, 42(15), 9807-9820 (2014-07-25)
Individuals with Fanconi anemia (FA) are susceptible to bone marrow failure, congenital abnormalities, cancer predisposition and exhibit defective DNA crosslink repair. The relationship of this repair defect to disease traits remains unclear, given that crosslink sensitivity is recapitulated in FA
Zhuang Wei et al.
Biochemical and biophysical research communications, 456(3), 750-756 (2014-12-17)
PTRF/cavin-1 is a protein of two lives. Its reported functions in ribosomal RNA synthesis and in caveolae formation happen in two different cellular locations: nucleus vs. plasma membrane. Here, we identified that the N-terminal leucine-zipper motif in PTRF/cavin-1 was essential
Lin-Sen Shi et al.
Molecular medicine reports, 10(6), 2898-2904 (2014-10-02)
Gastrokine‑2 is a putative gastric cancer‑specific tumor suppressor gene, the loss of which is known to be involved in the development and progression of gastric cancer, and restoration of gastrokine‑2 expression inhibits growth of gastric cancer cells in vitro. However
Yuichi Hashimoto et al.
Molecular and cellular biochemistry, 397(1-2), 147-155 (2014-08-21)
Humanin, a short bioactive peptide, inhibits a variety of cell deaths. Humanin-mediated inhibition of neuronal cell death, caused by an Alzheimer's disease (AD)-linked mutant gene occurs via binding of Humanin to its heterotrimeric Humanin receptor (htHNR), which results in the
Jia Qi et al.
Nature communications, 5, 5390-5390 (2014-11-13)
Electrical stimulation of the dorsal raphe (DR) and ventral tegmental area (VTA) activates the fibres of the same reward pathway but the phenotype of this pathway and the direction of the reward-relevant fibres have not been determined. Here we report
Joaquin Manzo-Merino et al.
Virology, 476, 100-105 (2014-12-30)
HPVs are the causative agents of approximately 5% of all human cancers, with cervical cancer being the most predominant. To understand the mechanism of action of the viral E6 oncoprotein, we analysed the effects of E6 upon potential cellular target
Ervin Nika et al.
The Biochemical journal, 463(1), 115-122 (2014-07-10)
PU.1 is essential for the differentiation of haemopoietic precursors and is strongly implicated in leukaemogenesis, yet the protein interactions that regulate its activity in different myeloid lineages are still largely unknown. In the present study, by combining fluorescent EMSA (electrophoretic
Shangfeng Zhao et al.
Neurological research, 36(5), 483-490 (2014-03-29)
Protein kinase B (PKB/Akt), which is phosphorylated and activated by upstream activators, exerts critical neuroprotective effects by phosphorylating downstream targets after traumatic brain injury (TBI). Studies on the regulation of Akt will be crucial for our understanding of neuronal survival.
Haoming Li et al.
In vitro cellular & developmental biology. Animal, 51(4), 329-335 (2014-12-06)
LIM-homeobox genes play a pivotal function in tissue patterning and differentiation, Lhx8 is a member of LIM-homeobox gene family, and it is selectively expressed in embryonic basal forebrain and is a key factor for the determination of cholinergic cells fate.
Mohammad Raies Ul Haq et al.
European journal of nutrition, 53(4), 1039-1049 (2013-10-30)
Recently, apprehension has been raised regarding "A1/A2 hypothesis" suggesting relationship between consumption of A1 "like" variants of cow β-casein and various physiological disorders. The information available is based on either the human epidemiological data of milk consumption or in vitro
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