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Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease.

Scientific reports (2019-09-08)
Silvia Carvajal, Meritxell Perramón, Denise Oró, Eudald Casals, Guillermo Fernández-Varo, Gregori Casals, Marina Parra, Bernardino González de la Presa, Jordi Ribera, Óscar Pastor, Manuel Morales-Ruíz, Víctor Puntes, Wladimiro Jiménez
ABSTRACT

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver disease. The aim of the current investigation was to elucidate whether CeO2NPs display beneficial effects in an experimental model of NAFLD.Therefore, fifteen Wistar rats were subjected to a methionine and choline deficient diet (MCDD) for 6 weeks and intravenously treated with CeO2NP or vehicle during the weeks three and four of the diet. The effect of CeO2NPs on serum biochemistry, hepatic steatosis, inflammation, fatty acid content and expression of reactive oxygen species (ROS) and lipid metabolism related genes was assessed. MCDD fed rats showed increased inflammation, enhanced hepatic lipid accumulation of both saturated and unsaturated fatty acids (FAs) and overexpression of genes related to fatty liver and ROS metabolism. Treatment with CeO2NPs was able to reduce the size and content of hepatocyte lipid droplets, the hepatic concentration of triglyceride- and cholesterol ester-derived FAs and the expression of several genes involved in cytokine, adipokine and chemokine signaling pathways. These findings suggest that CeO2NPs could be of beneficial value in NAFLD.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Boron trifluoride-methanol solution, 14% in methanol
Sigma-Aldrich
Butylated hydroxytoluene, ≥99%, FCC, FG