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Exfoliated near infrared fluorescent silicate nanosheets for (bio)photonics.

Nature communications (2020-03-22)
Gabriele Selvaggio, Alexey Chizhik, Robert Nißler, Llyas Kuhlemann, Daniel Meyer, Loan Vuong, Helen Preiß, Niklas Herrmann, Florian A Mann, Zhiyi Lv, Tabea A Oswald, Alexander Spreinat, Luise Erpenbeck, Jörg Großhans, Volker Karius, Andreas Janshoff, Juan Pablo Giraldo, Sebastian Kruss
ABSTRACT

Imaging of complex (biological) samples in the near-infrared (NIR) is beneficial due to reduced light scattering, absorption, phototoxicity, and autofluorescence. However, there are few NIR fluorescent materials known and suitable for biomedical applications. Here we exfoliate the layered pigment CaCuSi4O10 (Egyptian Blue, EB) via ball milling and facile tip sonication into NIR fluorescent nanosheets (EB-NS). The size of EB-NS can be tailored to diameters <20 nm and heights down to 1 nm. EB-NS fluoresce at 910 nm and the fluorescence intensity correlates with the number of Cu2+ ions. Furthermore, EB-NS display no bleaching and high brightness compared with other NIR fluorophores. The versatility of EB-NS is demonstrated by in-vivo single-particle tracking and microrheology measurements in Drosophila melanogaster embryos. EB-NS can be uptaken by plants and remotely detected in a low-cost stand-off detection setup. In summary, EB-NS have the potential for a wide range of bioimaging applications.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Carbon nanotube, single-walled, (6,5) chirality, ≥95% carbon basis (≥95% as carbon nanotubes), 0.78 nm average diameter