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Insecticidal anthranilic diamides: a new class of potent ryanodine receptor activators.

Bioorganic & medicinal chemistry letters (2005-09-17)
George P Lahm, Thomas P Selby, John H Freudenberger, Thomas M Stevenson, Brian J Myers, Gilles Seburyamo, Ben K Smith, Lindsey Flexner, Christopher E Clark, Daniel Cordova
ABSTRACT

A novel class of anthranilic diamides has been discovered with exceptional insecticidal activity on a range of Lepidoptera. These compounds have been found to exhibit their action by release of intracellular Ca2+ stores mediated by the ryanodine receptor. The discovery, synthesis, structure-activity, and biological results are presented.

MATERIALS
Product Number
Brand
Product Description

Supelco
Cypermethrin, PESTANAL®, analytical standard
Supelco
α-Cypermethrin, PESTANAL®, analytical standard
Supelco
Cypermethrin solution, 100 μg/mL in acetonitrile, PESTANAL®, analytical standard
Sigma-Aldrich
3-(Trifluoromethyl)pyrazole, 99%