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Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains.

Journal of the American Chemical Society (2010-04-29)
Benjamin M Swarts, Zhongwu Guo
ABSTRACT

A GPI anchor bearing unsaturated fatty acid lipid chains (1) was synthesized by a highly convergent strategy employing the para-methoxybenzyl group for permanent hydroxyl protection. The final global deprotection was achieved by an efficient three-step, one-pot procedure to give an 81% isolated yield of the target structure.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Anisole, ReagentPlus®, 99%
Supelco
Anisole, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Anisole, anhydrous, 99.7%
Sigma-Aldrich
Anisole, ≥99%, FCC, FG
Supelco
Anisole, analytical standard