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  • The intracerebroventricular injection of rimonabant inhibits systemic lipopolysaccharide-induced lung inflammation.

The intracerebroventricular injection of rimonabant inhibits systemic lipopolysaccharide-induced lung inflammation.

Journal of neuroimmunology (2015-08-25)
Arnold Johnson, Paul H Neumann, Jianya Peng, Janey James, Vincenzo Russo, Hunter MacDonald, Nancy Gertzberg, Carlos Feleder
ABSTRACT

We investigated the role of intracerebroventricular (ICV) injection of rimonabant (500ng), a CB1 antagonist, on lipopolysaccharide ((LPS) 5mg/kg)-induced pulmonary inflammation in rats in an isolated perfused lung model. There were decreases in pulmonary capillary pressure (Ppc) and increases in the ((Wet-Dry)/Dry lung weight)/(Ppc) ratio in the ICV-vehicle/LPS group at 4h. There were decreases in TLR4 pathway markers, such as interleukin receptor-associated kinase-1, IκBα, Raf1 and phospho-SFK (Tyr416) at 30min and at 4h increases in IL-6, vascular cell adhesion molecule-1 and myeloperoxidase in lung homogenate. Intracerebroventricular rimonabant attenuated these LPS-induced responses, indicating that ICV rimonabant modulates LPS-initiated pulmonary inflammation.

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