Chiral Phosphoric Acids: Versatile Organocatalysts with Expanding Applications


We are proud to offer a suite of BINOL-derived chiral phosphoric acids in our collection of products for asymmetric catalysis. This well established class of chiral Brønsted acid catalysts has been applied to an ever-increasing number of useful transformations.

BINOL-derived chiral phosphoric acids


  • Alternative to metal catalysts and chiral auxiliaries
  • Both enantiomers of catalyst are available
  • Relatively low catalyst loading (often 1-5 mol %)
  • High selectivity at non-cryogenic reaction temperatures (-30 to 23 °C)

Representative Applications

Reductive Amination
One of the earliest demonstrations of chiral phosphoric acid catalysis is the metal-free reduction of imines with an organic reductant (Hantzsch ester) to give enantioenriched amines.1

Reductive Amination

The enantioselective allylation of aldehydes can be accomplished under very mild conditions at non-cryogenic temperature (-30 °C).2


Friedel-Crafts Alkylation
Functionalized indoles3,4 and pyrroles5 can be accessed in enantioenriched form by asymmetric alkylation.

Friedel-Crafts Alkylation

Product Information

View the complete Chiral Phosphoric Acids product portfolio.