ALK
anaplastic lymphoma receptor tyrosine kinase
Synonymes:
CD246, NBLST3
Espèce(s):
Human ALK (238), Mouse Alk (11682), Rat Alk (266802), fruit fly Alk (53425), Zebrafish alk (563509), chicken ALK (421297), domestic cat ALK (101091689), dog ALK (483021), Horse ALK (100070891), sheep ALK (101114094) ...Plus
ID UniProtKB:
ID du gène:
- Human(238) Summary: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
- Mouse(11682) anaplastic lymphoma kinase
- Rat(266802) anaplastic lymphoma receptor tyrosine kinase
- fruit fly(53425) CG8250 gene product from transcript CG8250-RB
- Zebrafish(563509) anaplastic lymphoma kinase (Ki-1)
- chicken(421297) anaplastic lymphoma receptor tyrosine kinase
- domestic cat(101091689) anaplastic lymphoma receptor tyrosine kinase
- dog(483021) anaplastic lymphoma receptor tyrosine kinase
- Horse(100070891) anaplastic lymphoma receptor tyrosine kinase
- sheep(101114094) anaplastic lymphoma receptor tyrosine kinase
- domestic guinea pig(100732585) anaplastic lymphoma receptor tyrosine kinase
- naked mole-rat(101703312) anaplastic lymphoma receptor tyrosine kinase
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ELISA
Numéro du produit
Description
Espèce(s)
Antibodies
Numéro du produit
Description
Espèces réactives
Application
Anti-ALK Antibody, clone 8G7, ,
Espèces réactives
human
Application
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-ALK Antibody, clone ALK1, clone ALK1, from mouse,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-phospho-ALK (pTyr1604) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-ALK antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM361, purified immunoglobulin,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-ALK Antibody, clone 1D13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, mouse
Application
ELISA
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Small Molecule - Inhibitor
Numéro du produit
Description
Espèce(s)
esiRNA
Numéro du produit
Description
Espèce(s)