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Merck

FLT1

fms-related tyrosine kinase 1

Synonymes:
FLT, FLT-1, VEGFR-1, VEGFR1
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(2321) Summary: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
  • Mouse(14254) FMS-like tyrosine kinase 1
  • Rat(54251) FMS-related tyrosine kinase 1
  • domestic guinea pig(100732326) fms-related tyrosine kinase 1
  • Zebrafish(544667) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • dog(403727) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • domestic cat(101088292) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • sheep(443088) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • chicken(374100) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • Horse(100061940) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • cow(503620) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • Domestic Rabbit(100343352) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • Horse(100033957) fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
  • naked mole-rat(101711333) fms-related tyrosine kinase 1

Custom & Knockdown Gene Products

ELISA

Numéro du produit
Description
Espèce(s)
Human VEGFR1 ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Espèce(s)
human
Rat VEGFR1 ELISA, for serum, plasma and cell culture supernatants,
Espèce(s)
rat

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-1 antibody produced in mouse, clone FLT-11, ascites fluid,
Espèces réactives
human
Application
ELISA
immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

western blot
Monoclonal Anti-FLT1 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL0344, purified immunoglobulin, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-phospho-VEGFR1 (pTyr1333) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry

western blot
Anti-VEGF Receptor-1 Antibody, Chemicon®, from mouse,
Espèces réactives
human, mouse
Application
ELISA
western blot
Anti-phospho-VEGFR1 (pTyr1048) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry

Small Molecule - Inhibitor

Numéro du produit
Description
Espèce(s)
SU 4312, ≥98% (HPLC),
Espèce(s)
human
Axitinib, ≥98% (HPLC),
Espèce(s)
human
SU 5416, ≥98% (HPLC),
Espèce(s)
human, mouse
Sunitinib malate, ≥98% (HPLC),
Espèce(s)
human
Pazopanib, ,
Espèce(s)
human

Proteins

Numéro du produit
Description
Espèce(s)
VEGF Receptor-1 (Flt-1)/Fc Chimera human, >90% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder,
Espèce(s)
human
Flt1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Espèce(s)
human
FLT1 (784-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human

esiRNA

Numéro du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human FLT1,
Espèce(s)
human