MDM2
MDM2 oncogene, E3 ubiquitin protein ligase
Synonymes:
ACTFS, HDMX, hdm2
Espèce(s):
Human MDM2 (4193), Mouse Mdm2 (17246), Rat Mdm2 (314856), Horse MDM2 (100033891), Zebrafish mdm2 (30637), domestic cat MDM2 (493939), sheep MDM2 (101104979), cow MDM2 (540378), naked mole-rat Mdm2 (101724821), dog MDM2 (403693) ...Plus
ID UniProtKB:
ID du gène:
- Human(4193) Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
- Mouse(17246) transformed mouse 3T3 cell double minute 2
- Rat(314856) p53 E3 ubiquitin protein ligase
- Horse(100033891) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- Zebrafish(30637) transformed 3T3 cell double minute 2 homolog (mouse)
- domestic cat(493939) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- sheep(101104979) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- cow(540378) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- naked mole-rat(101724821) MDM2 oncogene, E3 ubiquitin protein ligase
- dog(403693) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
- domestic guinea pig(100724684) MDM2 oncogene, E3 ubiquitin protein ligase
- chicken(395609) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
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ELISA
Numéro du produit
Description
Espèce(s)
Antibodies
Numéro du produit
Description
Espèces réactives
Application
Anticorps anti-MDM2, clone IF2, clone IF2, from mouse,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-MDM2 (Ab-2) Mouse mAb (2A10), liquid, clone 2A10, Calbiochem®,
Espèces réactives
human
Application
Anti-MDM2 Antibody, clone 2A10, clone 2A10, from mouse,
Espèces réactives
human
Application
immunoprecipitation (IP)
western blot
western blot
Anti-Phospho-MDM2-S166 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
western blot
western blot
Anti-phospho-MDM2 (pSer166) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot