NCF4
neutrophil cytosolic factor 4, 40kDa
Synonymes:
NCF, P40PHOX, SH3PXD4
Espèce(s):
Human NCF4 (4689), Mouse Ncf4 (17972), Rat Ncf4 (500904), chicken NCF4 (418052), Zebrafish ncf4 (403014), domestic cat NCF4 (101095507), dog NCF4 (481277), cow NCF4 (507859), Horse NCF4 (100069566), sheep NCF4 (101122939) ...Plus
ID UniProtKB:
ID du gène:
- Human(4689) Summary: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(17972) neutrophil cytosolic factor 4
- Rat(500904) neutrophil cytosolic factor 4
- chicken(418052) neutrophil cytosolic factor 4, 40kDa
- Zebrafish(403014) neutrophil cytosolic factor 4
- domestic cat(101095507) neutrophil cytosolic factor 4, 40kDa
- dog(481277) neutrophil cytosolic factor 4, 40kDa
- cow(507859) neutrophil cytosolic factor 4, 40kDa
- Horse(100069566) neutrophil cytosolic factor 4, 40kDa
- sheep(101122939) neutrophil cytosolic factor 4, 40kDa
- Domestic Rabbit(100009359) neutrophil cytosolic factor 4, 40kDa
- domestic guinea pig(100729267) neutrophil cytosolic factor 4, 40kDa
- naked mole-rat(101699188) neutrophil cytosolic factor 4, 40kDa
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Antibodies
Numéro du produit
Description
Espèces réactives
Application
Anti-Phospho-NCF4-T154 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
western blot
Anti-NCF4 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
guinea pig, horse, human, rat
Application
western blot
Anti-NCF4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-NCF4/p40-phox Antibody, clone 4L9Z4, Rabbit Monoclonal, ,
Espèces réactives
mouse
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-NCF4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Proteins
Numéro du produit
Description
Espèce(s)