PLCE1
phospholipase C, epsilon 1
Synonymes:
NPHS3, PLCE, PPLC
Espèce(s):
Human PLCE1 (51196), Mouse Plce1 (74055), Rat Plce1 (114633), domestic guinea pig Plce1 (100721203), naked mole-rat Plce1 (101706315), sheep PLCE1 (101105703), Domestic Rabbit PLCE1 (100344504), dog PLCE1 (486808), domestic cat PLCE1 (101088695), Horse PLCE1 (100061676) ...Plus
ID UniProtKB:
ID du gène:
- Human(51196) Summary: This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
- Mouse(74055) phospholipase C, epsilon 1
- Rat(114633) phospholipase C, epsilon 1
- domestic guinea pig(100721203) phospholipase C, epsilon 1
- naked mole-rat(101706315) phospholipase C, epsilon 1
- sheep(101105703) phospholipase C, epsilon 1
- Domestic Rabbit(100344504) phospholipase C, epsilon 1
- dog(486808) phospholipase C, epsilon 1
- domestic cat(101088695) phospholipase C, epsilon 1
- Horse(100061676) phospholipase C, epsilon 1
- cow(519037) phospholipase C, epsilon 1
- Zebrafish(568288) phospholipase C, epsilon 1
- chicken(428962) phospholipase C, epsilon 1
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Antibodies
Numéro du produit
Description
Espèces réactives
Application
Anti-PLCE1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry