ALD00032

Sigma-Aldrich

1-(Oxazolo[4,5-b]pyridin-2-yl)-6-phenylhexan-1-one

Synonyme(s):
OL-100, 1-(Oxazolo[4,5-b]pyridin-2-yl)-1-oxo-6-phenylhexane, 1-Oxazolo[4,5-b]pyridin-2-yl-6-phenyl-1-hexanone
Empirical Formula (Hill Notation):
C18H18N2O2
Numéro CAS:
Poids moléculaire:
294.35
ID de substance PubChem:
NACRES:
NA.22

Niveau de qualité

100

Forme

solid

Temp. de stockage

−20°C

SMILES string

O=C(C1=NC2=C(C=CC=N2)O1)CCCCCC3=CC=CC=C3

InChI

1S/2C18H18N2O2/c2*21-15(18-20-17-16(22-18)12-7-13-19-17)11-6-2-5-10-14-8-3-1-4-9-14/h2*1,3-4,7-9,12-13H,2,5-6,10-11H2

InChI key

LFAKEBRRAYWLPI-UHFFFAOYSA-N

Application

Inhibitor of Fatty acid amide hydrolase (FAAH); a serine hydrolase resposible for the transformation of anandamide to arachidonic acid

Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide

Conditionnement

1 mg in clear glass bottle

Pictograms

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

RID ADR

NONH for all modes of transport

WGK Allemagne

WGK 3

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
Contenu apparenté
As the exploration of the properties of complex natural products becomes increasingly more sophisticated with the technological advances being made in their screening and evaluation and as structural details of their interaction with biological targets becomes more accessible, the importance and opportunities for providing unique solutions to complex biological problems has grown. The Boger Lab addresses these challenging problems by understanding the complex solutions and subtle design elements that nature has provided in the form of a natural product and work to extend the solution through rational design elements to provide more selective, more efficacious, or more potent agents designed specifically for the problem or target under investigation. The resulting efforts have reduced many difficult or intractable synthetic challenges to manageable problems providing an approach not only to the natural product but one capable of simple extrapolation to a series of structural analogs with improved selectivity and efficacy.
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