MABC598

Sigma-Aldrich

Anti-PACS2 Antibody, clone 9F12.2

clone 9F12.2, from mouse

Synonyme(s):
Phosphofurin acidic cluster sorting protein 2, PACS1-like protein, PACS2
eCl@ss:
32160702
NACRES:
NA.41

Niveau de qualité

100

Source biologique

mouse

antibody product type

primary antibodies

Clone

9F12.2, monoclonal

species reactivity

mouse, rat

Application(s)

western blot: suitable

Isotype

IgG1κ

N° d'accession NCBI

N° d'accession UniProt

Expédié(e)(s) dans

wet ice

Description générale

Phosphofurin acidic cluster sorting protein 2 (PACS2), also known as PACS-2, PACS1-like protein, and encoded by the gene name PACS2/ KIAA0602/ PACS1L, is a amember of the PACS family. PACS2 is a multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. Additionally, PACS2 translocates BIB to mitochondria in response to apoptic inducers, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome C, and the activation of caspase-3 thereby causing cell death. Recent studies have indicated that PACS2 may also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. PACS2 interacts with BID, PKD2, and HIV-1 Nef.

Immunogène

GST-tagged recombinant protein corresponding to Human PACS2.

Application

Research Sub Category
Apoptosis - Additional
Western Blotting Analysis: A 1:500 dilution from a representative lot detected PACS2 in 10 µg of mouse hypothalamus tissue.
Research Category
Apoptosis & Cancer
This Anti-PACS2 antibody is validated for use in Western Blotting for the detection of PACS2.

Qualité

Evaluated by Western Blotting in rat hippocampus tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected PACS2 in 10 µg of rat hippocampus tissue lysate.

Description de la cible

~100 kDa observed

Forme physique

Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Allemagne

WGK 1

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

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