15205

Blasticidine S hydrochloride

• Synonym(s): Blasticidin S
• Empirical Formula (Hill Notation): C₁₇H₂₆N₈O₅ · HCl
• CAS Number: 3513-03-9
• Molecular Weight: 458.90
• Numéro MDL: MFCD02091640
• ID de substance PubChem: 57647341

Properties

• Forme: powder
• Niveau de qualité: 200
• Couleur: white to off-white
• Solubilité: acetic acid: water: soluble, clear, colorless
• Spectre d'activité de l'antibiotique: fungi
• application(s): agriculture; environmental
• Mode d’action: protein synthesis | interferes
• Expédié(e)(s) dans: dry ice
• Temp. de stockage: −20°C
• SMILES string: Cl[H].CN(CC[C@@H](N)CC(=O)N[C@H]1C=C[C@@H](O[C@@H]1C(O)=O)N2C=CC(N)=NC2=O)C(N)=N
• InChI: 1S/C17H26N8O5.ClH/c1-24(16(20)21)6-4-9(18)8-12(26)22-10-2-3-13(30-14(10)15(27)28)25-7-5-11(19)23-17(25)29;/h2-3,5,7,9-10,13-14H,4,6,8,18H2,1H3,(H3,20,21)(H,22,26)(H,27,28)(H2,19,23,29);1H/t9-,10+,13-,14+;/m1./s1
• InChI key: YQXYQOXRCNEATG-ZAYJLJTISA-N

Description

Description générale

Blasticidin S belongs to the aminoacylnucleoside class of antibiotics. It inhibits protein synthesis in bacteria and eukaryotes. It also has fungicidal properties and prevents rice blast disease.

Chemical structure: nucleoside

Application

Blasticidin S is used as a selection agent for transformed cells that contain the resistance genes bls, bsr, or BSD. Blasticidiin S has been used to select HEK293-T cells with TLR-2 constructs and HEK-D5 cells . It is also used to study protein synthesis at the level of peptide bond formation.

Conditionnement

25, 100 mg

Bottomless glass bottle. Contents are inside inserted fused cone.

Actions biochimiques/physiologiques

Blasticidin S inhibits hydrolysis of peptidyl-tRNA induced by release factors. It enhances the binding of tRNA to the large subunit of ribosomes and to an extent inhibits peptide bond formation.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. Storage class (TRGS 510): Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

Safety Information

• Pictograms: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300
• Conseils de prudence: P264 - P270 - P301 + P310 + P330 - P405 - P501
• Classification des risques: Acute Tox. 1 Oral
• Code de la classe de stockage: 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 2
• Flash Point(F): Not applicable
• Point d'éclair C: Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges