51060

Guanosine 5′-diphosphate disodium salt

≥90% (HPLC)

• Synonym(s): 5′-GDP-Na₂
• Empirical Formula (Hill Notation): C₁₀H₁₃N₅Na₂O₁₁P₂
• CAS Number: 7415-69-2
• Molecular Weight: 487.16
• Numéro EC: 231-026-2
• Numéro MDL: MFCD00084665
• ID de substance PubChem: 57651304
• NACRES: NA.51

Properties

• Source biologique: Porcine brain; microbial (Corynebacterium sp); synthetic
• Niveau de qualité: 100
• Essai: ≥90% (HPLC)
• Forme: powder
• Solubilité: H₂O: 50 mg/mL, clear, colorless
• Expédié(e)(s) dans: dry ice
• Temp. de stockage: −20°C
• SMILES string: [Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
• InChI key: LTZCGDIGAHOTKN-LGVAUZIVSA-L

Description

Description générale

Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.

Application

Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.

Guanosine 5′-diphosphate disodium salt has been used:

• in fluorescent metal nanoclusters selectivity of guanosine 3′-diphosphate-5′-di(tri)phosphate, ppGpp
• in screening of fluorescence emission of hypocrellin A-zinc complex
• as a component of assay buffers in the autoradiography of mice brain sections

Actions biochimiques/physiologiques

Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).

Safety Information

• Code de la classe de stockage: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Point d'éclair C: Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)