This canavanine product was successfully employed to run yeast fluctuation tests.
C9758
L-Canavanine sulfate salt
plant seeds (Jack bean ), ≥99% (TLC), iNOS inhibitor, powder
L-Canavanine sulfate salt
Synonyme(s) :
L-α-Amino-γ-(guanidinooxy)butyric acid sulfate salt
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| Conditionnement | Référence | Disponibilité | Prix |
|---|---|---|---|
| 100 mg | Vérifier la disponibilité des articles du panier | 48,20 € | |
| 250 mg | Vérifier la disponibilité des articles du panier | 61,10 € | |
| 1 g | Disponible dès aujourd'huiDeSt QuentinFallavier | 205,00 € | |
| 5 g | Vérifier la disponibilité des articles du panier | 788,00 € |
A propos de cet article
Formule empirique (notation de Hill) :
C5H12N4O3 · H2SO4
Numéro CAS:
Poids moléculaire :
274.25
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
218-728-4
MDL number:
Beilstein/REAXYS Number:
6121291
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Laissez-nous vous aiderNom du produit
L-Canavanine sulfate salt, ≥99% (TLC), powder
biological source
plant seeds (Jack bean )
Quality Level
assay
≥99% (TLC)
form
powder
color
white
mp
160-165 °C (dec.)
solubility
H2O: 100 mg/mL
storage temp.
2-8°C
SMILES string
OS(O)(=O)=O.N[C@@H](CCONC(N)=N)C(O)=O
InChI
1S/C5H12N4O3.H2O4S/c6-3(4(10)11)1-2-12-9-5(7)8;1-5(2,3)4/h3H,1-2,6H2,(H,10,11)(H4,7,8,9);(H2,1,2,3,4)/t3-;/m0./s1
InChI key
MVIPJKVMOKFIEV-DFWYDOINSA-N
Gene Information
human ... NOS2(4843)
General description
Canavanine is a homolog of arginine and a non-protein amino acid. It is present in plants like alfalfa, cloves, beans onions and sprouts.[1] Canavanine is synthesized from L-canavaninosuccinic acid and the biosynthetic pathway was first elucidated in jack bean plant.
Application
Canavanine sulfate salt has been used:
- as a translation inhibitor in yeast translation studies
- as a component of synthetic complete (SC) drop-out medium for screening yeast
- for screening Saccharomyces cerevisiae in canavanine mutation frequency assay
Biochem/physiol Actions
Naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS).
Naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes; selective inhibitor of inducible nitric oxide synthase (iNOS).
Canavanine is a naturally occurring L-amino acid that competes and interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid.[1] It is a selective inhibitor of inducible nitric oxide synthase (iNOS). It acts as a substrate for arginyl tRNA and is incorporated during protein synthesis leading to aberrant canavanyl proteins. Supplementation with canavanine worsens the alfalfa induced Systemic lupus erythematosus (SLE) like syndrome and its incorporation with endosome and proteasome disrupts the antigen processing.[1]
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Cet article | |||
|---|---|---|---|
| biological source plant seeds (Jack bean ) | biological source Canavalia ensiformis | biological source - | biological source - |
| assay ≥99% (TLC) | assay ≥98% (TLC) | assay 98% | assay ≥97% |
| Gene Information human ... NOS2(4843) | Gene Information - | Gene Information - | Gene Information human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| form powder | form powder | form crystals | form powder |
| solubility H2O: 100 mg/mL | solubility H2O: <100 mg/mL | solubility - | solubility H2O: 50 mg/mL, ethanol: insoluble |
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Toshiya Ogata et al.
Cell biology international, 40(1), 100-106 (2015-10-29)
A mitochondrial superoxide dismutase (SOD2) is the first line of antioxidant defense against mitochondrial superoxide. Even though the involvement of SOD2 in lifespan has been studied extensively in several organisms, characterization of the aging process has not been performed for
L-canavanine, a selective inhibitor of inducible NO synthase, increases plasma endothelin-1 concentrations in dogs with endotoxic shock
Mitaka C, et al.
Journal of Critical Care, 16(1), 17-23 (2001)
High-throughput transformation of Saccharomyces cerevisiae using liquid handling robots
Liu G, et al.
PLoS ONE, 12(3), e0174128-e0174128 (2017)
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| C9758-5G | 04061833531129 |
| C9758-250MG | 04061835512386 |
| C9758-100MG | 04061833531105 |
| C9758-1G | 04061833531112 |