Endothelin 1

≥97% (HPLC), powder

Empirical Formula (Hill Notation):
Numéro CAS:
Poids moléculaire:
Numéro MDL:
ID de substance PubChem:

Niveau de qualité


Source biologique



≥97% (HPLC)




ELISA: suitable




1% acetic acid: >1 mg/mL
H2O: >1 mg/mL

N° d'accession UniProt

Temp. de stockage


SMILES string




InChI key


Gene Information

human ... EDN1(1906)

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Amino Acid Sequence

Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp [Disulfide Bridges: 1-15; 3-11]

Description générale

Endothelin-1 (ET-1) is synthesized and secreted by activated endothelial cells, and is a peptide with potent vasoconstrictor activity. It is a marker for activated or dysfunctional endothelial cells. This peptide is one of the three isopeptides belonging to the endothelin family. It is also released by cardiomyocytes.


Endothelin-1 (ET-1) has been used to study the production and detection of H2O2 and production of NO in the presence of ET-1, for studying the effects of ET-1 on the eNOS/inducible NOS (iNOS)/caveolin-1 expression, NO production, isoform specific PKC translocation, and PKC activity in human saphenous vein endothelial cells (HSVECs).

Actions biochimiques/physiologiques

Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.
Endothelin-1 (ET-1) is a vasoconstrictor, which is increased in plasma and explants of patients with uterine leiomyomas. Thus, uterine fibroids are linked to increased ET-1 levels and hypertension, which is worsened by hypoxic condtions. ET-1 RNAi and Endostar are capable of preventing the progression and invasiveness of PC-3 (prostate cancer) cells. The plasma levels of this peptide are increased in patients with atrial septal defect (ASD), and these levels might help in diagnosis of closure defects. The plasma level of ET-1 is also higher in patients with end-stage renal disease (ESRD), and this is linked to gradual worsening of pulmonary function tests.

Autres remarques

The biological source is human endothelin, which shares the same sequence
A synthetic peptide with the sequence of human and porcine Endothelin 1.
Lyophilized from 0.1% TFA in H2O


13 - Non Combustible Solids

WGK Allemagne


Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificat d'analyse

Certificat d'origine

Monika Komar et al.
Cardiovascular ultrasound, 12, 31-31 (2014-08-08)
The study aimed to assess the level of plasma Endothelin-1 (ET-1) in patients before and after transcatheter closure of atrial septal defect (ASD) and to evaluate the usefulness of measuring ET-1 levels for the diagnosis and selection of candidates for...
Stephen Wedgwood et al.
American journal of physiology. Lung cellular and molecular physiology, 288(3), L480-L487 (2004-11-09)
Similar to infants born with persistent pulmonary hypertension of the newborn (PPHN), there is an increase in circulating endothelin-1 (ET-1) and decreased endothelial nitric oxide synthase (eNOS) gene expression in an ovine model of PPHN. These abnormalities lead to vasoconstriction...
Hao-Jie Zhang et al.
Asian Pacific journal of cancer prevention : APJCP, 15(23), 10079-10083 (2015-01-06)
Endothelin-1 and Endostar are both significant for the progression, proliferation, metastasis and invasion of cancer. In this paper, we studied the effect of ET-1 RNAi and Endostar in PC-3 prostatic cancer cells. The lentiviral vector was used in the establishment...
Javid Safa et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 25(4), 781-787 (2014-06-28)
End-stage renal disease (ESRD) is a complex illness that involves different organs including the lungs. We studied the pulmonary function tests, arterial blood gases (ABG) and plasma endothelin-1 (ET-1) levels to check whether there is any change in their levels...
Zachary Barrett-O'Keefe et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 70(5), 554-565 (2014-05-14)
The endothelin-1 vasoconstrictor pathway contributes to age-related elevations in resting peripheral vascular tone primarily through activation of the endothelin subtype A (ET(A)) receptor. However, the regulatory influence of ET(A)-mediated vasoconstriction during exercise in the elderly is unknown. Thus, in 17...

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