F4381

Sigma-Aldrich

Furosemide

Synonyme(s):
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
Empirical Formula (Hill Notation):
C12H11ClN2O5S
Numéro CAS:
Poids moléculaire:
330.74
Numéro EC:
Numéro MDL:
ID de substance PubChem:
NACRES:
NA.77

Niveau de qualité

200

Source biologique

synthetic (organic)

Essai/Dosage

≥98% (HPLC)

Forme

powder

Pf

220 °C (dec.) (lit.)

Solubilité

acetone: 50 mg/mL, clear to slightly hazy, faintly yellow to yellow

Auteur

Sanofi Aventis

Temp. de stockage

room temp

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

Gene Information

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Description générale

Furosemide is a an ototoxic high-ceiling diuretic.

Application

Furosemide has been used:
  • to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
  • to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
  • as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Conditionnement

1, 5, 10, 25 g in glass bottle

Actions biochimiques/physiologiques

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.
Furosemide can block the Na+/K+/2Cl- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.
Inhibits ion co-transport in the kidney.

Caractéristiques et avantages

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations légales

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Pictograms

Exclamation markHealth hazard

Mention d'avertissement

Danger

Mentions de danger

hazcat

Acute Tox. 4 Oral - Repr. 1B

storage_class_code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK Allemagne

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Certificat d'analyse

Certificat d'origine

Furosemide
Saunders Handbook of Veterinary Drugs - E-Book (2016)
Causes of acquired hearing loss
Eggermont J J
Hearing Loss: Causes, Prevention, and Treatment (2017)
Comparison of arterial pressure and plasma AngII responses to three methods of subcutaneous AngII administration
Kuroki M T, et al.
American Journal of Physiology. Heart and Circulatory Physiology (2014)
Topiramate is more effective than acetazolamide at lowering intracranial pressure
Scotton W J, et al.
Cephalalgia, 0333102418776455-0333102418776455 (2018)
Diuretics
Side Effects of Drugs Annual, 28, 233-243 (2005)
Contenu apparenté
Discover Bioactive Small Molecules for ADME/Tox
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