Merck
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G8168

Sigma-Aldrich

G 418 disulfate salt solution

50 mg/mL in H2O, 0.1 μm filtered, BioReagent, suitable for cell culture

Synonym(s):
Antibiotic G418
Empirical Formula (Hill Notation):
C20H40N4O10 · 2H2SO4
CAS Number:
Molecular Weight:
692.71
Numéro MDL:
ID de substance PubChem:
NACRES:
NA.76

Source biologique

Micromonospora echinospora

Niveau de qualité

200

Stérilité

0.1 μm filtered

Gamme de produits

BioReagent

Forme

solution

Puissance

50-60 mg per mL

Poids mol.

692.7

Conditionnement

pkg of 10 and 100 mL

Concentration

50 mg/mL in H2O

technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Couleur

colorless

Solubilité

H2O: 50 mg/mL, clear

Spectre d'activité de l'antibiotique

parasites

Mode d’action

protein synthesis | interferes

Temp. de stockage

2-8°C

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](OC[C@@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O

InChI

1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1

InChI key

UHEPSJJJMTWUCP-NKCAIAFTSA-N

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Description générale

Chemical structure: aminoglycoside

Application

G418 disulfate is an aminoglycoside antibiotic similar in structure to gentamicin used for selection and maintenance of prokaryotic and eukaryotic cells. Optimal concentrations for selection and maintenance vary by cell lines. Bacteria and algae require 5 μg/mL or less while animal cells may require 300-500 μg/mL.

Actions biochimiques/physiologiques

Mode of Action: G418 blocks polypeptide synthesis and protein elongation by inhibiting synthesis at the 70S and 80S ribosomes.

Antimicrobial Spectrum: G418 selects for cells stably transfected with an iNOS promoter construct and neomycin resistance gene and shows activity against protozoa and helminthes.

Attention

The product is stable for two years when stored at 2-8°C.

Pictograms

Health hazard

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Resp. Sens. 1 - Skin Sens. 1

Code de la classe de stockage

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificate of Analysis

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Certificate of Origin

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