GW20087F

Sigma-Aldrich

Anti-Human Kappa Light Chain antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonyme(s):
Anti-Immunoglobulin kappa
Numéro MDL:

Source biologique

chicken

Niveau de qualité

200

Forme d'anticorps

affinity isolated antibody

antibody product type

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-20087F

Application(s)

western blot: suitable

Conjugué

unconjugated

N° d'accession UniProt

Expédié(e)(s) dans

wet ice

Temp. de stockage

−20°C

Gene Information

human ... IGKC(3514)

Immunogène

Human IgK (Kappa) native protein.

Application

Anti-Human Kappa Light Chain antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Actions biochimiques/physiologiques

Immunoglobulin κ constant (IGKC) is a human gene that encodes the constant domain of κ-type light chains for antibodies. It is found on chromosome 2 in humans. IGKC acts as a strong prognostic marker in several human solid tumors, including breast cancer. Its expression may have a role for humoral immunity in breast cancer progression. IGKC is also found to be expressed in non-small lung cancer (NSCLC) and may act as a prognostic marker in NSCLC, supporting emerging treatment concepts that exploit the humoral immune response. Its has an independent protective impact on disease-free survival (DFS) and breast cancer-specific overall survival in node-negative breast cancer. IGKC acts as a novel diagnostic marker for risk stratification in human cancer and may help to exploit the humoral immune response for anticancer therapy.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

RID ADR

NONH for all modes of transport

WGK Allemagne

WGK 2

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
Zonglin Chen et al.
PloS one, 7(9), e44741-e44741 (2012-10-03)
Biomarkers of the immune system are currently not used as prognostic factors in breast cancer. We analyzed the association of the B cell/plasma cell marker immunoglobulin kappa C (IGKC) and survival of untreated node-negative breast cancer patients. IGKC expression was...
Janardan P Pandey et al.
Immunobiology, 219(2), 113-117 (2013-09-24)
Immunoglobulin κ constant (IGKC) gene has recently been identified as a strong prognostic marker in several human solid tumors, including breast cancer. Although the mechanisms underlying the IGKC signature are not yet known, identification of tumor-infiltrating plasma cells as the...
Miriam Lohr et al.
Cancer letters, 333(2), 222-228 (2013-02-02)
A prognostic impact of immunoglobulin kappa C (IGKC) expression has been described in cancer. We analysed the influence of B-cell and plasma cell markers, as well as IGKC expression, in non-small lung cancer (NSCLC) using immunohistochemistry on a tissue microarray....
Marcus Schmidt et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(9), 2695-2703 (2012-02-22)
Although the central role of the immune system for tumor prognosis is generally accepted, a single robust marker is not yet available. On the basis of receiver operating characteristic analyses, robust markers were identified from a 60-gene B cell-derived metagene...
Torben Knuschke et al.
Nanomedicine : nanotechnology, biology, and medicine, 10(8), 1787-1798 (2014-07-12)
Retroviral infections e.g. HIV still represent a unique burden in the field of vaccine research. A common challenge in vaccine design is to find formulations that create appropriate immune responses to protect against and/or control the given pathogen. Nanoparticles have...

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