Merck
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I0634

Sigma-Aldrich

Ionomycin calcium salt from Streptomyces conglobatus

powder, ≥98% (HPLC)

Synonym(s):
SQ23377 calcium
Empirical Formula (Hill Notation):
C41H70CaO9
CAS Number:
Molecular Weight:
747.07
Beilstein:
1416163
Numéro MDL:
ID de substance PubChem:
NACRES:
NA.77

Niveau de qualité

300

Essai/Dosage

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated
protect from light

Couleur

white to off-white

Solubilité

DMSO: 10 mg/mL
ethanol: soluble

Spectre d'activité de l'antibiotique

Gram-positive bacteria

Mode d’action

cell membrane | interferes

Temp. de stockage

2-8°C

SMILES string

C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O

InChI

1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1

InChI key

WKRWUYKLUMMAKG-WYGBAUISSA-L

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Application

Ionomycin calcium salt from Streptomyces conglobatus has been used as a media supplement to culture:
  • peripheral blood mononuclear cells (PBMCs) for immunologic assessment
  • oocytes for parthenogenetic activation
  • T cell subsets for the detection of intracellular cytokines, carboxyfluorescein diacetate succinimidyl ester (CFSE) proliferation assay and antigen-specific suppressive function assay

Conditionnement

1, 5 mg in glass bottle

Actions biochimiques/physiologiques

Ca2+ ionophore that is more effective than A23187 as a mobile ion carrier for Ca2+; non-fluorescent; used to study Ca2+ transport across biological membranes; induces apoptotic degeneration of embryonic cortical neurons.
Ionomycin is an ionophore, widely used for validation and calibration of calcium analysis.

Notes préparatoires

Store ionomycin in powder form desiccated and protected from light at 2-8 °C. Under these conditions the product is stable for 3 years. Store stock solutions in ethanol or DMSO at -20 °C, protected from light. Under these conditions the stock solutions are stable for several months. For short term use (up to 6 weeks) the stock solutions maybe stored at 2-8 °C protected from light.

Pictograms

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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