PLA0106

Sigma-Aldrich

Rabbit anti-MSH2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonyme(s):
FCC1, mutS homolog 2, LCFS2, COCA1, MutS protein homolog 2, HNPCC, nonpolyposis type 1, nonpolyposis type 1 (E. coli), HNPCC1, mutS (E. coli) homolog 2 (colon cancer; nonpolyposis type 1), colon cancer, hMSH2
NACRES:
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity purified immunoglobulin

antibody product type

primary antibodies

Qualité

Powered by Bethyl Laboratories, Inc.

species reactivity

human, mouse

Application(s)

immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:1,000-1:5,000

N° d'accession

P43246

N° d'accession UniProt

Expédié(e)(s) dans

wet ice

Temp. de stockage

2-8°C

Gene Information

rabbit ... MSH2(4436)

Immunogène

The epitope recognized by PLA0106 maps to a region between residues 1 and 50 of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).

Forme physique

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Autres remarques

MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC).

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RID ADR

NONH for all modes of transport

WGK Allemagne

nwg

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
Raul Alvarado-Bachmann et al.
Molecular medicine reports, 10(2), 1003-1006 (2014-05-27)
Knowledge of the molecular biology of primary colorectal cancer (CRC) has improved in recent years, and one reason for this is the identification of microsatellite instability (MSI), which occurs in up to 15% of sporadic CRC. However, less is known...
Kimberly C Wiegand et al.
Human pathology, 45(6), 1258-1268 (2014-04-29)
ARID1A/BAF250a has been recently implicated as a tumor suppressor in gastric cancer. We sought to clarify the clinical significance of BAF250a/ARID1A in relation to other clinical parameters and relevant biomarkers in gastric carcinoma. Cases from 2 separate cohorts of patients...
Anne-Sophie Bats et al.
Anticancer research, 34(6), 3211-3215 (2014-06-13)
To assess the feasibility of Microsatellite Instability (MSI) analysis in uterine cavity washings for detecting endometrial cancer in Lynch syndrome. This was a proof-of-concept study in Lynch syndrome patients, scheduled for hysterectomy. At the beginning of surgical procedure, uterine cavity...

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