PRS3459

Sigma-Aldrich

Anti-Caspase-1 (ab1) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s):
Anti-ICE, Anti-Caspase 1, apoptosis-related cysteine peptidase (Interleukin 1, beta, convertase), Anti-IL-1β converting enzyme
Numéro MDL:

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

antibody product type

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

species reactivity

human

Application(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Conjugué

unconjugated

N° d'accession UniProt

Expédié(e)(s) dans

dry ice

Temp. de stockage

−20°C

Gene Information

human ... CASP1(834)

Description générale

Caspase-1 is also known as interleukin-1β converting enzyme (ICE). It is located on chromosome 11q22.2. It has 10 exons, an N terminal CARD (caspase activation and recruitment domain), a large P20 subunit and a small P10 subunit. It is present in leukocytes, monocytes and epithelial cells.

Immunogène

a 16 amino acid peptide from near the carboxy-terminus of human Caspase-1.

Application

Anti-Caspase-1 (ab1) antibody produced in rabbit has been used in western blotting and immunofluorescence staining.

Actions biochimiques/physiologiques

Caspase-1 can transform the pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18 into their active forms. It participates in pyroptosis. It is overexpressed in the aorta of coronary atherosclerosis patients. It helps in host cell survival by inducing membrane biogenesis to restore the impairment caused by pore-forming toxins.

Liaison

The action of this antibody can be blocked using blocking peptide SBP3459.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RID ADR

NONH for all modes of transport

WGK Allemagne

WGK 2

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes
Chen Q, et al.
The Journal of Biological Chemistry, 290(43), 26051-26058 (2015)
Defects in MAP1S-mediated autophagy turnover of fibronectin cause renal fibrosis
Xu G, et al.
Aging (Albany. NY.), 8(5), 977-985 (2016)
Qi Chen et al.
The Journal of biological chemistry, 290(43), 26051-26058 (2015-09-13)
Autophagy is a cellular process that controls and executes the turnover of dysfunctional organelles and misfolded or abnormally aggregated proteins. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) activates the initiation of autophagy. Autophagosomes migrate along acetylated microtubules to...
Min-Yao Jiang et al.
Oncotarget, 8(46), 80295-80302 (2017-11-09)
Benign prostatic hyperplasia (BPH) is one of the most common diseases in the senior men and age plays an important role in the initiation and development of BPH. Mammalian cells primarily use the autophagy-lysosome system to degrade misfolded/aggregated proteins and...
Guibin Xu et al.
Aging, 8(5), 977-985 (2016-05-30)
Excessive deposition of extracellular matrix proteins in renal tissues causes renal fibrosis and renal function failure. Mammalian cells primarily use the autophagy-lysosome system to degrade misfolded/aggregated proteins and dysfunctional organelles. MAP1S is an autophagy activator and promotes the biogenesis and...

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique

Réseaux sociaux

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

Merck

Recherche. Développement. Production

Nous sommes un des tout premiers fournisseurs du secteur mondial des Sciences de la vie proposant des solutions et des services pour la recherche, le développement et la production en biotechnologies, et le développement et la production de produits thérapeutiques pharmaceutiques.

© 2021 Merck KGaA, Darmstadt, Allemagne et/ou ses sociétés affiliées. Tous droits réservés.

La reproduction d'une quelconque partie du contenu de ce site est strictement interdite sans autorisation.