RAB1351

Sigma-Aldrich

Human CD74 ELISA

for serum, plasma and cell culture supernatants

NACRES:
NA.32

species reactivity

human

Conditionnement

kit of 96 wells (12 strips x 8 wells)

Application(s)

ELISA: suitable

input

sample type cell culture supernatant(s)
sample type plasma
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.1 ng/mL
standard curve range: 0.102-25 ng/mL

detection method

colorimetric

Expédié(e)(s) dans

wet ice

Temp. de stockage

−20°C

Gene Information

human ... CD74(972)

Description générale

The CD74 (HLA-DR (human leukocyte antigen – antigen D related) antigens-associated invariant chain) gene encodes for a type II transmembrane protein and is expressed by antigen presenting cells such as monocytes, B cells, macrophages and dendritic cells. The CD74 gene is mapped to human chromosome 5q33.1.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached
Protocolfor details.

Actions biochimiques/physiologiques

CD74 (HLA-DR (human leukocyte antigen – antigen D related) antigens-associated invariant chain) is part of major histocompatibility complex (MHC) class II and its function is associated with antigen presentation. Upregulation of the CD74 gene is observed cancer including breast cancer and it is known to promote to metastasis. CD74 also serves as a cytokine receptor in immune and epithelial cells. It induces cellular processes such as cell proliferation, migration and survival pathways.

Autres remarques

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Pictograms

Corrosion

Mention d'avertissement

Warning

Mentions de danger

RID ADR

UN 3264 8 / PGIII

WGK Allemagne

WGK 3

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
Van?den Berghe?s 5q?syndrome in 2008.
Mohamedali A and Mufti G J
British Journal of Haematology, 144(2), 157-168 (2009)
CD74 and intratumoral immune response in breast cancer.
Wang Z Q, et al.
Oncotarget, 8(8), 12664-12664 (2017)
GSK-3?-mediated fatty acid synthesis enhances epithelial to mesenchymal transition of TLR4-activated colorectal cancer cells through regulation of TAp63.
Park G B, et al.
International Journal of Oncology, 49(5), 2163-2172 (2016)
Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74.
Meza-Romero R, et al.
Cytokine, 88, 62-70 (2016)
CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells.
Liu Z, et al.
Oncotarget, 7(42), 68303-68303 (2016)

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