SMB00607

Sigma-Aldrich

Amoxicillin trihydrate: potassium clavulanate (4:1)

Synonyme(s):
Amoxicillin Trihydrate: Potassium Clavulanate
NACRES:
NA.85

Forme

powder

Niveau de qualité

200

Conditions de stockage

(Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.)

Couleur

off-white

Solubilité

water: 1 mg/mL

Mode d’action

cell wall synthesis | interferes

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria

Temp. de stockage

2-8°C

Catégories apparentées

Description générale

Amoxicillin trihydrate is a semisynthetic antibiotic, that is used as a medicine.

Application

Amoxicillin trihydrate: potassium clavulanate (4:1) has been used to study its effect on the viral déjà vu disease (neonatal intracerebral (i.c.) infection) in mice model.

Actions biochimiques/physiologiques

Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria. Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes.

Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.

Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.

Conditionnement

1G

Composants

Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.

Pictograms

FlameHealth hazard

Mention d'avertissement

Danger

Mentions de danger

Risques supp

EUH014 - EUH044

RID ADR

NONH for all modes of transport

WGK Allemagne

WGK 2

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
Preparation and characterization of Sn/Zn/TiO2 photocatalyst for enhanced amoxicillin trihydrate degradation
Mohammadi R, et al.
Desalination and Water Treatment, 53(7), 1995-2004 (2015)
Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
Di Liberto G, et al.
Cell (2018)
A P Ball et al.
Lancet (London, England), 1(8169), 620-623 (1980-03-22)
Clavulanic acid is an inhibitor of certain beta-lactamases, notably those enzymes which inactivate the penicillins and cause resistance of important bacteria to these antibiotics. Microbiological, pharmacological, and clinical studies show that clavulanic acid in combination with amoxycillin is effective and...
In vitro antimicrobial activity of 6(D(-) -amino-p-hydroxyphenylacetamido) penicillanic acid, a new semisynthetic penicillin.
H C Neu et al.
Antimicrobial agents and chemotherapy, 10, 407-410 (1970-01-01)
R N Brogden et al.
Drugs, 18(3), 169-184 (1979-09-01)
Amoxycillin, an acid stable semisynthetic penicillin shown to be effective against a wide range of infections when given orally, is now available for intramuscular and intravenous injection. Amoxycillin has an antibacterial spectrum and level of activity essentially the same as...

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