SML0323

Sigma-Aldrich

SMI-4a

≥98% (HPLC)

Synonyme(s):
(Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione, (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
Empirical Formula (Hill Notation):
C11H6F3NO2S
Numéro CAS:
Poids moléculaire:
273.23
Numéro MDL:
ID de substance PubChem:

Niveau de qualité

100

Essai/Dosage

≥98% (HPLC)

Forme

powder

Couleur

white to beige

Solubilité

DMSO: >10 mg/mL

Temp. de stockage

2-8°C

SMILES string

FC(F)(F)c1cccc(\C=C2/SC(=O)NC2=O)c1

InChI

1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-

InChI key

NGJLOFCOEOHFKQ-YVMONPNESA-N

Conditionnement

10, 50 mg in glass bottle

Actions biochimiques/physiologiques

SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.

Pictograms

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

Conseils de prudence

RID ADR

NONH for all modes of transport

WGK Allemagne

3

Certificat d'analyse
Certificat d'origine
Rui-Fang Fan et al.
Molecular medicine reports, 16(4), 4603-4612 (2017-08-30)
The development of targeted tyrosine kinase inhibitors (TKIs) has succeeded in altering the course of chronic myeloid leukemia (CML). However, a number of patients have failed to respond or experienced disease relapse following TKI treatment. Proviral integration site for moloney murine...
null
Jinxuan Wang et al.
International immunopharmacology, 73, 568-574 (2019-06-17)
PIM kinase is involved in the cellular processes of growth, differentiation and apoptosis. However, the role of PIM1 in lipopolysaccharide (LPS)-induced acute lung injury (ALI) remains largely unknown. A trend of PIM1 in the lung tissue of LPS-induced ALI at...
Xinyi Zhang et al.
Molecular immunology, 125, 15-22 (2020-07-04)
PIM1 is serine/threonine protein kinase that is involved in numerous biological processes. Pulmonary fibrosis (PF) is a chronic pathological result of the dysfunctional repair of lung injury without effective therapeutic treatments. In the current study, we investigated whether PIM1 inhibition...
Shiro Fujii et al.
British journal of haematology, 180(2), 246-258 (2018-01-13)
Proviral Integrations of Moloney virus 2 (PIM2) is overexpressed in multiple myeloma (MM) cells, and regarded as an important therapeutic target. Here, we aimed to validate the therapeutic efficacy of different types of PIM inhibitors against MM cells for their...

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