Merck
All Photos(1)

SML1571

Sigma-Aldrich

S14161

≥98% (HPLC)

Synonym(s):
8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-1-benzopyran, 8-Ethoxy-2-(4-fluorophenyl)-3-nitro-2H-chromene, Pichromene
Empirical Formula (Hill Notation):
C17H14FNO4
CAS Number:
Molecular Weight:
315.30
Numéro MDL:
ID de substance PubChem:
NACRES:
NA.77

Niveau de qualité

100

Essai/Dosage

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated
protect from light

Couleur

white to beige

Temp. de stockage

−20°C

SMILES string

FC(C=C1)=CC=C1C2C([N+]([O-])=O)=CC3=CC=CC(OCC)=C3O2

InChI

1S/C17H14FNO4/c1-2-22-15-5-3-4-12-10-14(19(20)21)16(23-17(12)15)11-6-8-13(18)9-7-11/h3-10,16H,2H2,1H3

InChI key

BFZXDHIUPNWOMT-UHFFFAOYSA-N

Conditionnement

1, 5 mg in glass bottle

Actions biochimiques/physiologiques

S14161 inhibits D-cyclin transactivation by inhibition of phosphoinositide 3-kinase (PI3K) activity. S14161 is a pan-class I PI3K inhibitor. S14161 inhibited the activity of all 4 isoforms of the PI3K class I family, and unlike LY294002, had little effect on class IV enzymes mechanistic target of rapamycin (mTOR) and DNA-PKcs (DNA-dependent protein kinase, catalytic subunit), or on AKT-1, -2, or -3 or PDK1. S14161 inhibited the expression of cyclins D1, D2, and D3, leading to the arrest of cells at the G0/G1 phase, and has exhibited anti-myeloma and anti-leukemia activity with no gross toxicity.

Pictograms

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

Classification des risques

Skin Irrit. 2

Code de la classe de stockage

11 - Combustible Solids

WGK

WGK 3

Certificate of Analysis

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Certificate of Origin

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