TFF3 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Intestinal trefoil factor, TFI, Trefoil Factor 3

Source biologique



expressed in E. coli


≥98% (HPLC)
≥98% (SDS-PAGE)




1.0-10.0 mg per mL

Poids mol.

13.2 kDa


pkg of 20 μg


cell culture | mammalian: suitable


<0.1 EU/μg endotoxin, tested



N° d'accession UniProt

Expédié(e)(s) dans

wet ice

Temp. de stockage


Gene Information

human ... TFF3(7033)

Description générale

The trefoil factor peptides (TFF1, TFF2 and TFF3) are secreted in the gastrointestinal tract. They are secreted peptides which are protease-resistant. TFF-3 is expressed by goblet cells and in the uterus, and has also been shown to be expressed in certain cancers, including colorectal, hepatocellular, and in biliary tumors. Recombinant human TFF3 is a 13.2kDa homodimeric protein consisting of two 59 amino acid chains, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.

Actions biochimiques/physiologiques

The trefoil factor peptides (TFF1, TFF2 and TFF3) appear to play an important role in intestinal mucosal defense and repair. TFF3 may be useful as a molecular marker for certain types of cancer, but its role, if any, in tumorigenesis is unknown. TFF3 also promotes airway epithelial cell migration and differentiation.



Forme physique

Lyophilized with no additives.


Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.


NONH for all modes of transport

WGK Allemagne


Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
P-O Lafontaine et al.
Journal francais d'ophtalmologie, 26(10), 1007-1014 (2003-12-24)
Trefoil factor family (TFF) peptides (formerly P-domain peptides; trefoil factor) are small (7-12 kDa) protease-resistant secreted peptides designated pS2 (or TFF1), SP (TFF2) and ITF (TFF3). Human conjunctival goblet cells (GCs) are known to synthesize TFF, but TFF expression by...
Shu Q Liu et al.
PloS one, 8(10), e77732-e77732 (2013-11-10)
Cerebral ischemia, while causing neuronal injury, can activate innate neuroprotective mechanisms, minimizing neuronal death. In this report, we demonstrate that experimental cerebral ischemia/reperfusion injury in the mouse causes upregulation of the secretory protein trefoil factor 3 (TFF3) in the hepatocyte...
Dale Porter et al.
Molecular cancer research : MCR, 1(5), 362-375 (2003-03-26)
Gene expression patterns in ductal carcinoma in situ (DCIS), and in invasive, and metastatic breast tumors were determined using serial analysis of gene expression (SAGE). We used mRNA in situ hybridization to examine gene expression at the cellular level and...
Ting-yi Du et al.
PloS one, 8(11), e80271-e80271 (2013-11-28)
Trefoil factor 3 (TFF3) is a small peptide that plays an important role in mucosal protection, cell proliferation, and cell migration. The aberrant expression of TFF3 is correlated with gastrointestinal inflammation, solid tumors, and other clinical diseases. The objective of...
Steen Seier Poulsen et al.
Regulatory peptides, 126(3), 163-171 (2005-01-25)
Peptides of the trefoil factor family (TFF1, TFF2 and TFF3) are cosecreted with mucus from mucus-producing cells in most organ systems and are believed to interact with mucus to form high-viscosity stable gel complexes. In the gastrointestinal tract, they sustain...

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