SRP5072

Sigma-Aldrich

PTPN11 (246-593), active, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s):
MGC14433, BPTP3, CFC, PTP2C, SH-PTP2, PTP-1D, NS1, SH-PTP3
NACRES:
NA.32

Recombinant

expressed in E. coli

Essai/Dosage

≥70% (SDS-PAGE)

Forme

buffered aqueous glycerol solution

specific activity

507-687 nmol/min·mg

Poids mol.

~69 kDa

N° d'accession NCBI

Expédié(e)(s) dans

dry ice

Temp. de stockage

−70°C

Gene Information

human ... PTPN11(5781)

Description générale

Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration

Forme physique

Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.

Notes préparatoires

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

RID ADR

NONH for all modes of transport

WGK Allemagne

WGK 1

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
U Dechert et al.
Human genetics, 96(5), 609-615 (1995-11-01)
A 2.1-kb cDNA probe encoding the human SH2-domain containing protein-tyrosine phosphatase SH-PTP2 (PTPN11) was hybridized to human metaphase chromosomes in three independent experiments. In each instance, hybridization was maximal to chromosome 12q24.1-q24.3. The presence of SH-PTP2 cDNA crosshybridizing sequences located...
S Ahmad et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(6), 2197-2201 (1993-03-15)
A cDNA encoding a nontransmembrane protein-tyrosine phosphatase (PTP; EC 3.1.3.48), termed PTP2C, was isolated from a human umbilical cord cDNA library. The enzyme contains a single phosphatase domain and two adjacent copies of the src homology 2 (SH2) domain at...

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