SRP6003

Sigma-Aldrich

Procalcitonin human

recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)

Synonyme(s):
CGRP, CALC1, CALCA, Calcitonin
Numéro CAS:
NACRES:
NA.32

Source biologique

human

Recombinant

expressed in E. coli

Essai/Dosage

≥97% (HPLC)
≥97% (SDS-PAGE)

Forme

lyophilized

Puissance

80 ng/mL

Poids mol.

12.796 kDa

Conditionnement

pkg of 10 μg

Application(s)

cell culture | mammalian: suitable

Impuretés

Endotoxin, tested

N° d'accession NCBI

Expédié(e)(s) dans

wet ice

Temp. de stockage

−20°C

Gene Information

human ... N/A(796)

Description générale

The gene CALC1 (calcitonin 1) is mapped to human chromosome 11. CALC1 encodes for preprocalcitonin. Preprocalcitonin is cleaved by endopeptidase at the amino-terminal to produce procalcitonin. Procalcitonin works as a peptide hormone and is mainly produced by the C cells of the thyroid and certain endocrine cells of the lung. Under normal expression conditions, procalcitonin is immediately cleaved into three specific fragments, an N terminal residue, calcitonin and katacalcin. Recombinant human procalcitonin produced in Escherichia coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids with a molecular weight of 12,796 Daltons.

Application

Procalcitonin human has been used in in vitro vascular permeability assay.

Actions biochimiques/physiologiques

Procalcitonin is a prohormone of calcitonin. Levels of unprocessed procalcitonin rise significantly after bacterial infection, trauma or shock. Procalcitonin is also associated with systemic complications in humans suffering from acute pancreatitis.

Forme physique

Lyophilized from a 10 mM sodium phosphate buffer, pH 7.5.

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in sterile H?O to a concentration of 0.1 mg/ml.

RID ADR

NONH for all modes of transport

WGK Allemagne

WGK 3

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis.
Rau B
Gut, 41, 832-832 (1997)
Nana-Maria Wagner et al.
Anesthesia and analgesia, 124(3), 836-845 (2016-09-23)
Procalcitonin is used as a diagnostic tool for the identification and risk stratification of septic patients. Procalcitonin plasma concentrations tightly correlate with the severity of the ongoing inflammatory reaction and can rise up to 10,000-fold. Impairment of endothelial cell function...
Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis.
Uzzan B
Critical Care Medicine, 34, 1996-1996 (2006)
Procalcitonin as an acute phase marker.
Annals of Clinical Biochemistry, 38, 483-493 (2001)
Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis.
Simon L
Clinical Infectious Diseases, 39, 206-217 (2004)

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