SRP6062

Sigma-Aldrich

PP2C α human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonyme(s):
PP2CA, Protein phosphatase 1A, PP1A, PPM1A
Numéro CAS:
NACRES:
NA.32

Source biologique

human

Recombinant

expressed in E. coli

Essai/Dosage

≥95% (SDS-PAGE)

Forme

liquid

Poids mol.

46.6 kDa (418aa)

Conditionnement

pkg of 100 μg

N° d'accession NCBI

Expédié(e)(s) dans

dry ice

Temp. de stockage

−70°C

Gene Information

human ... PPM1A(5494)

Description générale

Protein phosphatase 2C-α (PP2C-α), also referred to as protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A), is encoded by the gene mapped to human chromosome 4q12. The encoded protein belongs to the family of Ser/Thr protein phosphatases. It is characterized with a catalytic subunit and a constant regulatory subunit. PP2C-α is abundantly expressed in heart and skeletal muscle.

Actions biochimiques/physiologiques

Protein phosphatase 2C-α (PP2C-α) is known to be a negative regulator of cell stress response pathways. Additionally, it has been reported to negatively regulate transforming growth factor-β (TGF-β) signaling pathway and cell cycle. PP2C-α has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control. It modulates cell migration and invasion.

Séquence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWILMGAF LDKPKMEKHN AQGQGNGLRY GLSSMQGWRV EMEDAHTAVI GLPSGLESWS FFAVYDGHAG SQVAKYCCEH LLDHITNNQD FKGSAGAPSV ENVKNGIRTG FLEIDEHMRV MSEKKHGADR SGSTAVGVLI SPQHTYFINC GDSRGLLCRN RKVHFFTQDH KPSNPLEKER IQNAGGSVMI QRVNGSLAVS RALGDFDYKC VHGKGPTEQL VSPEPEVHDI ERSEEDDQFI ILACDGIWDV MGNEELCDFV RSRLEVTDDL EKVCNEVVDT CLYKGSRDNM SVILICFPNA PKVSPEAVKK EAELDKYLEC RVEEIIKKQG EGVPDLVHVM RTLASENIPS LPPGGELASK RNVIEAVYNR LNPYKNDDTD STSTDDMW

Forme physique

1 mg/mL solution in 10 mM Tris-HCl, pH 7.5, 50 mM NaCl, 2 mM DTT, 1 mM MnCl2, 20% glycerol.

Notes préparatoires

Centrifuge the vial prior to opening.

Pictograms

Exclamation mark

Mention d'avertissement

Warning

Mentions de danger

RID ADR

NONH for all modes of transport

WGK Allemagne

WGK 3

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
The cloning expression and tissue distribution of human PP2Cβ.
Anna E M, et al.
Febs Letters, 431(1), 121-124 (1998)
Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.
Mazur S J, et al.
Biochemistry, 56(21), 2676-2689 (2017)
Integrated analysis of expression and genome alteration reveals putative amplified target genes in esophageal cancer.
Takashi S, et al.
Oncology Letters, 18(2), 465-472 (2007)
Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway.
Geng J, et al.
Oncotarget, 5(14), 5700-5711 (2014)
PPM1A Methylation Is Associated With Vascular Recurrence in Aspirin-Treated Patients.
Gallego-Fabrega C, et al.
Stroke, 47(7), 1926-1929 (2016)

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