SRP6330

Sigma-Aldrich

CD46 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

Synonyme(s):
MCP, Membrane cofactor protein isoform 14, AHUS2, TLX, TRA2.10, MIC10
NACRES:
NA.32

Source biologique

human

Recombinant

expressed in E. coli

Essai/Dosage

≥85% (SDS-PAGE)

Forme

liquid

Poids mol.

33.8 kDa (302 aa, 35-313 aa + His tag)

Conditionnement

pkg of 100 μg

Concentration

1 mg/mL

Impuretés

<1 EU/μg endotoxin (LAL test)

N° d'accession UniProt

Expédié(e)(s) dans

dry ice

Temp. de stockage

−70°C

Gene Information

human ... CD46(4179)

Description générale

Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Forme physique

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.

RID ADR

NONH for all modes of transport

WGK Allemagne

WGK 3

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
Maximilian Richter et al.
Molecular therapy. Methods & clinical development, 5, 16013-16013 (2016-04-14)
Rituximab is a mouse/human chimeric monoclonal antibody targeted toward CD20. It is efficient as first-line therapy of CD20-positive B-cell malignancies. However, a large fraction of treated patients relapse with rituximab-resistant disease. So far, only modest progress has been made in...
Ying Yan et al.
Neuroscience letters, 701, 100-105 (2019-02-19)
P2X4 receptor (P2X4R), a subtype of P2 purinergic receptors, is an ATP-gated receptor through which activity of spinal microglia instigates pain hypersensitivity in various pain conditions. Accumulating evidence indicates that monocyte chemoattractant protein-1 (MCP-1) plays an important role in chronic...
Jian Du et al.
Veterinary microbiology, 195, 87-95 (2016-10-25)
The outbreak of Chinese Giant Salamander (Andrias davidianus, CGS) Iridovirus (CGSIV) caused massive death of CGSs. However, some CGSs with low level of CGSIV usually could survive. In our study, major capsid protein (MCP) DNA replicates of CGSIV in shedding...
Yi-Jun Jia et al.
Fish & shellfish immunology, 100, 317-323 (2020-03-17)
Largemouth bass ulcerative syndrome virus (LBUSV) is an important virus induce the mortality of largemouth bass (Micropterus Salmoides). In this study, we reported a single-walled carbon nanotubes (SWCNTs) containing LBUSV major capsid protein (MCP) subunit vaccine (SWCNTs-MCP) which was evaluated...
Shao-Yeh Lu et al.
Applied and environmental microbiology, 85(11) (2019-03-25)
Microcin PDI (MccPDI), a class IIa microcin that is produced by Escherichia coli strains 25 and 284, is known to inhibit foodborne pathogenic enterohemorrhagic E. coli serotypes O157:H7 and O26. Here we demonstrate that MccPDI can inhibit Shigella strains and...

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