Merck
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SRP6330

Sigma-Aldrich

CD46 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

Synonym(s):
AHUS2, MCP, MIC10, Membrane cofactor protein isoform 14, TLX, TRA2.10
NACRES:
NA.32

Source biologique

human

Recombinant

expressed in E. coli

Essai/Dosage

≥85% (SDS-PAGE)

Forme

liquid

Poids mol.

33.8 kDa (302 aa, 35-313 aa + His tag)

Conditionnement

pkg of 100 μg

Concentration

1 mg/mL

Impuretés

<1 EU/μg endotoxin (LAL test)

N° d'accession UniProt

Expédié(e)(s) dans

dry ice

Temp. de stockage

−70°C

Gene Information

human ... CD46(4179)

Description générale

Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Forme physique

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.

Code de la classe de stockage

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificate of Analysis

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Certificate of Origin

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