SRP6517

Sigma-Aldrich

Alpha 2HS Glycoprotein from human plasma

≥90% (SDS-PAGE)

Synonyme(s):
Fetuin-A, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein
NACRES:
NA.32

Source biologique

human

Essai/Dosage

≥90% (SDS-PAGE)

Forme

lyophilized

Poids mol.

49 kDa

Conditionnement

pkg of 1 mg

N° d'accession UniProt

Expédié(e)(s) dans

wet ice

Temp. de stockage

−20°C

Gene Information

human ... AHSG(197)

Description générale

AHSG (α2-HS glycoprotein), or fetuin-A, is a predominant serum glycoprotein with a molecular weight of 64kDa, and is produced and secreted primarily by hepatic cells. It is highly present in the extracellular matrix (ECM) of the bone.

Actions biochimiques/physiologiques

AHSG (α2-HS glycoprotein) is a multifunctional protein, and acts as an inhibitor of insulin receptor tyrosine kinase. It is involved in insulin resistance by promoting adipose tissue inflammation by functioning as a ligand for Toll-like receptor 4. Therefore, it is linked to the type 2 diabetes. This protein plays a crucial role in the prevention of extracellular calcification. This protein is a candidate plasma biomarker for early hypopharyngeal squamous cell carcinoma (HSCC) diagnosis. It is also a negative acute-phase protein, and its serum levels reduce drastically following surgeries, trauma, burns, and severe inflammation. Studies in Chinese populations show the serum levels of this protein is linked with fatty liver index (FLI), alanine aminotransferance (ALT), and aspartate aminotransferance (AST), which are early indicators of nonalcoholic fatty liver disease (NAFLD).

Forme physique

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

RID ADR

NONH for all modes of transport

WGK Allemagne

WGK 3

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Certificat d'analyse
Certificat d'origine
Serum Fetuin-A Associated With Fatty Liver Index, Early Indicator of Nonalcoholic Fatty Liver Disease: A Strobe-Compliant Article.
Huang Y et al
Medicine, 94(39), e1517-e1517 (2015)
Allelic Imbalance of mRNA Associated with a2-HS Glycoprotein (Fetuin-A) Polymorphism.
Inaoka Y et al
Disease Markers, 2015, 865053-865053 (2015)
Wen-Dong Tian et al.
International journal of clinical and experimental pathology, 8(8), 9021-9031 (2015-10-16)
Hypopharyngeal squamous cell carcinoma (HSCC) has very poor prognosis compared with other head and neck squamous cell carcinomas. Late-stage diagnosis of HSCC increases mortality. Therefore, more effective biomarkers for early diagnosis of HSCC are necessary. Unfortunately, appropriate biomarkers for clinical...

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