T6397

Sigma-Aldrich

3,3′,5-Triiodo-L-thyronine sodium salt

powder, BioReagent, suitable for cell culture

Synonyme(s):
Liothyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine sodium salt, T3
Empirical Formula (Hill Notation):
C15H11I3NNaO4
Numéro CAS:
Poids moléculaire:
672.96
Beilstein/REAXYS Number:
8179867
Numéro EC:
Numéro MDL:
ID de substance PubChem:
NACRES:
NA.77

Niveau de qualité

200

Source biologique

synthetic

Gamme de produits

BioReagent

Essai/Dosage

≥95%

Forme

powder

Puissance

0.02-50 ng/mL (lit.)

Application(s)

cell culture | mammalian: suitable

Solubilité

ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow

Expédié(e)(s) dans

ambient

Temp. de stockage

−20°C

SMILES string

[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O

InChI

1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1

InChI key

SBXXSUDPJJJJLC-YDALLXLXSA-M

Gene Information

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Catégories apparentées

Description générale

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level. Thyroxine (T4) serves as a precursor for T3 and is generated in extrathyroidal tissues.

Application

3,3′,5-Triiodo-L-thyronine sodium salt has been used for inducing thyroid hormone manipulations in mice. It has also been used In cell culturing of hippocampal, retinal, proximal tubule and glomerular explant.

Actions biochimiques/physiologiques

3,3′,5′-Triiodo-L-thyronine (T3) increases the rates of protein synthesis, stimulates the breakdown of cholesterol and effects embryonic development. In cell culture, T3 regulates cell differentiation and protein expression. The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissues and affect a number of metabolic processes. The level of circulating T3 hormone is reduced in hypothyroidism.

Forme physique

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Reconstitution

To prepare 20 μg/ml stock solution: add 1ml 1N NaOH per mg 3,3′, 5-triiodo-L-thyronine; gently swirl to dissolve. To this, add 49 ml sterile medium per ml 1N NaOH added.

storage_class_code

13 - Non Combustible Solids

WGK Allemagne

WGK 3

Flash Point(F)

Not applicable

Point d'éclair C

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificat d'analyse

Certificat d'origine

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1
Sussman MA, et al.
The Journal of Clinical Investigation, 105(7), 875-886 (2000)
Medical Biochemistry, 769-769 (2001)
Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha
Neumann H, et al.
The Journal of Experimental Medicine, 185(2), 305-316 (1997)
Hormones Growth Factors & Oncogenes, 219-219 (1987)
Handbook of Behavior, Food and Nutrition, 2109-2109 (2011)
Protocoles
HPLC Analysis of Levothyroxine and Liothyronine on Ascentis® Express ES-Cyano
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