Molecular biology of the cell, 29(13), 1555-1570 (2018-05-03)
Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring. The signals underlying these differing pathways are complex and incompletely
American journal of physiology. Renal physiology, 304(1), F19-F30 (2012-10-19)
Diabetic nephropathy is the most common cause of end-stage renal disease and is a major risk factor for cardiovascular disease. In the United States, microvascular complications during diabetic nephropathy contribute to high morbidity and mortality rates. However, the cell-autonomous impact
Developmental dynamics : an official publication of the American Association of Anatomists, 237(7), 1837-1850 (2008-06-24)
Olfactory sensory neuron (OSN) axons follow stereotypic spatio-temporal paths in the establishment of the olfactory pathway. Extracellular matrix (ECM) molecules are expressed early in the developing pathway and are proposed to have a role in its initial establishment. During later
Tissue engineering. Part A, 20(21-22), 2892-2907 (2014-05-16)
Induction of morphogenesis by competent lung progenitor cells in a 3D environment is a central goal of pulmonary tissue engineering, yet little is known about the microenvironmental signals required to induce de novo assembly of alveolar-like tissue in vitro. In
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(30), 9405-9416 (2009-07-31)
We recently described the boundary-like expression pattern of the extracellular matrix molecule tenascin-C (Tnc) in the developing mouse olfactory bulb (OB) (Shay et al., 2008). In the present study, we test the hypothesis that Tnc inhibits olfactory sensory neuron (OSN)
Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells.
Palenski, TL; Sorenson, CM; Jefcoate, CR; Sheibani, N
Laboratory Investigation; a Journal of Technical Methods and Pathology null
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(27), 10101-10114 (2011-07-08)
Many primary vestibular afferents form large cup-shaped postsynaptic terminals (calyces) that envelope the basolateral surfaces of type I hair cells. The calyceal terminals both respond to glutamate released from ribbon synapses in the type I cells and initiate spikes that
The choroidal circulation plays a central role in maintaining the health of outer retina and photoreceptor function. Alterations in this circulation contribute to pathogenesis of many eye diseases including exudative age-related macular degeneration. Unfortunately, very little is known about the
Cytochrome P450 1B1 (CYP1B1) is a member of the cytochrome p450 family of enzymes that catalyze mono-oxygenase reactions. Although constitutive Cyp1b1 expression is limited in hepatocytes, its expression and function in liver sinusoidal endothelial cells (LSEC) remains unknown. Here we
Interleukin-8 (IL-8) is upregulated in fibrotic and malignant diseases and is a key mediator of proliferative responses. Elevated IL-8 was recently correlated with benign prostatic hyperplasia epithelium and a myofibroblast reactive stroma. Thus, we sought to determine whether overexpressed IL-8
Satellite cell activity is differentially affected by contraction mode in human muscle following a work-matched bout of exercise.
Hyldahl, RD; Olson, T; Welling, T; Groscost, L; Parcell, AC
While considerable progress has been made towards understanding the complex processes and pathways that regulate human wound healing, regenerative medicine has been unable to develop therapies that coax the natural wound environment to heal scar-free. The inability to induce perfect
TGF-?1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse.
Barron, DA; Strand, DW; Ressler, SJ; Dang, TD; Hayward, SW; Yang, F; Ayala, GE; Ittmann et al.
The International journal of developmental biology, 53(4), 641-648 (2009-02-28)
In the prospective lumbo-sacral region of the chick embryo, neurulation is achieved by cavitation of the medullary cord, a process called secondary neurulation. Neural crest cells (NCC) are generated in this region and they give rise to the same types
Hyaluronic acid, HAS1, and HAS2 are significantly upregulated during muscle hypertrophy.
Calve, S; Isaac, J; Gumucio, JP; Mendias, CL
American Journal of Physiology. Cell Physiology null
Vestibular hair cells in the inner ear encode head movements and mediate the sense of balance. These cells undergo cell death and replacement (turnover) throughout life in non-mammalian vertebrates. However, there is no definitive evidence that this process occurs in
Biochimica et biophysica acta, 1802(7-8), 659-672 (2010-04-15)
Neuraminidase 1 (NEU1) regulates the catabolism of sialoglycoconjugates in lysosomes. Congenital NEU1 deficiency in children is the basis of sialidosis, a severe neurosomatic disorder in which patients experience a broad spectrum of clinical manifestations varying in the age of onset
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(6), 2538-2545 (2012-03-15)
During forelimb regeneration in the newt Notophthalmus viridescens, the dynamic expression of a transitional matrix rich in hyaluronic acid, tenascin-C, and fibronectin controls muscle cell behavior in vivo and in vitro. However, the influence of extracellular matrix (ECM) remodeling on
Development (Cambridge, England), 147(9) (2020-05-14)
Osteoblasts arise from bone-surrounding connective tissue containing tenocytes and fibroblasts. Lineages of these cell populations and mechanisms of their differentiation are not well understood. Screening enhancer-trap lines of zebrafish allowed us to identify Ebf3 as a transcription factor marking tenocytes
Neurodegenerative disorders include wide range of conditions, which affect millions of people worldwide. Unfortunately, they are incurable and irreversibly progressive. Immunohistochemical staining of paraffin-fixed tissues for both diagnostic and research purposes are widely used. However, large amount of brain tissues
American journal of physiology. Lung cellular and molecular physiology, 306(7), L620-L634 (2013-12-10)
Pigment epithelium-derived factor (PEDF) is a multifunctional protein with important roles in regulation of inflammation and angiogenesis. It is produced by various cell types, including endothelial cells (EC). However, the cell autonomous impact of PEDF on EC function needs further
Archives of toxicology, 93(2), 417-434 (2018-11-01)
The cellular and molecular events that precede hair cell (HC) loss in the vestibular epithelium during chronic ototoxic exposure have not been widely studied. To select a study model, we compared the effects of sub-chronic exposure to different concentrations of
Fibrous development of the extracellular matrix (ECM) of cardiac valves is necessary for proper heart function. Pathological remodeling of valve ECM is observed in both pediatric and adult cardiac disorders. It is well established that intracardiac hemodynamics play a significant
Fluorescent whole-mount method for visualizing three-dimensional relationships in intact and regenerating adult newt spinal cords.
Zukor, KA; Kent, DT; Odelberg, SJ
Developmental Dynamics null
Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress.
American journal of physiology. Cell physiology, 311(3), C418-C436 (2016-07-22)
Defects in the outer blood-retinal barrier have significant impact on the pathogenesis of diabetic retinopathy and macular edema. However, the detailed mechanisms involved remain largely unknown. This is, in part, attributed to the lack of suitable animal and cell culture
Development of a reactive stroma associated with prostatic intraepithelial neoplasia in EAF2 deficient mice.
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