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C Z Camargo et al.
Scandinavian journal of rheumatology, 44(1), 48-55 (2014-11-08)
To evaluate the morphological and functional abnormalities of the microcirculation associated with markers of vascular injury in patients with early systemic sclerosis (SSc). Forty-six patients with early SSc were compared with 80 patients with definite SSc, 40 patients with primary...
Joshua S Speed et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4937-4944 (2015-08-14)
The current study was designed to determine whether vascular endothelial-derived endothelin-1 (ET-1) is important for skin Na(+) buffering. In control mice (C57BL/6J), plasma Na(+) and osmolarity were significantly elevated in animals on high- vs. low-salt (HS and LS, respectively) intake....
Michael DeNiro et al.
PloS one, 9(7), e101602-e101602 (2014-07-23)
Retinal ischemia promotes the upregulation of VEGF expression and accounts for most pathological features of retinal neovascularization (NV). Paradoxically, VEGF remains the pivotal stimulator of ocular NV, despite the absence of ischemia. Therefore, the central question arises as to how...
Junlan Zhang et al.
The American journal of pathology, 184(6), 1706-1714 (2014-04-16)
Hepatic production and release of endothelin-1 (ET-1) binding to endothelin B (ETB) receptors, overexpressed in the lung microvasculature, is associated with accumulation of pro-angiogenic monocytes and vascular remodeling in experimental hepatopulmonary syndrome (HPS) after common bile duct ligation (CBDL). We...
Philip Hasbak et al.
Journal of cardiovascular pharmacology, 63(1), 58-67 (2013-10-03)
This study describes the effect of variable oxygen supply on relaxing responses induced by α-calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) on isolated pig coronary arteries in vitro. Organ culture during normoxia (21% of O₂) and hypoxia (5% of O₂)...
Katja Haedicke et al.
Nature biomedical engineering, 4(3), 286-297 (2020-03-14)
The monitoring of vascular-targeted therapies using magnetic resonance imaging, computed tomography or ultrasound is limited by their insufficient spatial resolution. Here, by taking advantage of the intrinsic optical properties of haemoglobin, we show that raster-scanning optoacoustic mesoscopy (RSOM) provides high-resolution...
Patricia Pais-Roldán et al.
NeuroImage, 189, 615-630 (2019-02-02)
Despite the association between brainstem lesions and coma, a mechanistic understanding of coma pathogenesis and recovery is lacking. We developed a coma model in the rat mimicking human brainstem coma, which allowed multimodal analysis of a brainstem tegmentum lesion's effects...
Zaid H Maayah et al.
BMC cancer, 20(1), 751-751 (2020-08-14)
The survival rates of women with breast cancer have improved significantly over the last four decades due to advances in breast cancer early diagnosis and therapy. However, breast cancer survivors have an increased risk of cardiovascular complications following chemotherapy. While...
Lei Li et al.
Molecular pharmaceutics, 11(7), 2009-2015 (2014-03-29)
Microfluidic devices have emerged as revolutionary, novel platforms for in vitro drug evaluation. In this work, we developed a facile method for evaluating antihypertensive drugs using a microfluidic chip. This microfluidic chip was generated using the elastic material poly(dimethylsiloxane) (PDMS)...
Er-Ning Su et al.
Investigative ophthalmology & visual science, 56(6), 4029-4037 (2015-06-23)
Cannabinoids have been reported to mediate changes in vascular resistance through endothelial receptor targets. We examined involvement of the endothelium in cannabinoid-mediated vasoactive responses in resistance arterioles of the retina. Vascular responses to both intraluminal (IL) and extraluminal (EL) administration...
Terika P Smith et al.
Blood cells, molecules & diseases, 54(2), 155-159 (2014-12-10)
Children with sickle cell disease (SCD) have painful vaso-occlusive episodes (VOEs), which often reoccur across the individual's lifespan. Vaso-constrictive and vaso-dilatory molecules have been hypothesized to play a role in VOEs. Endothelin-1 (ET-1) is a potent vasoconstrictor that is released...
F D Russell et al.
Trends in pharmacological sciences, 21(9), 353-359 (2000-09-06)
Endothelin-1 (ET-1) is synthesized, stored and released in the human heart. On release, ET-1 has the potential to activate specific receptors in a paracrine manner to modify heart function directly. Two binding sites corresponding to endothelin ETA and ETB receptors...
Francesca Spinella et al.
The Journal of biological chemistry, 277(31), 27850-27855 (2002-05-25)
Angiogenesis is an essential prerequisite for tumor growth, invasion, and metastasis. In ovarian carcinoma cells, endothelin-1 (ET-1) stimulates the secretion of vascular endothelial growth factor (VEGF), a major mediator of tumor angiogenesis. In OVCA 433 and HEY ovarian carcinoma cell...
Jean-Luc Morel et al.
Pflugers Archiv : European journal of physiology, 466(8), 1517-1528 (2013-11-16)
Microgravity induces a redistribution of blood volume. Consequently, astronauts' body pressure is modified so that the upright blood pressure gradient is abolished, thereby inducing a modification in cerebral blood pressure. This effect is mimicked in the hindlimb unloaded rat model....
Sebastien Trachsel et al.
Journal of applied physiology (Bethesda, Md. : 1985), 118(6), 768-775 (2015-01-01)
Inhaled nitric oxide (INO) improves ventilation-perfusion matching and alleviates pulmonary hypertension in patients with acute respiratory distress syndrome. However, outcome has not yet been shown to improve, and nonresponse is common. A better understanding of the mechanisms by which INO...
L Andrique et al.
Science advances, 5(6), eaau6562-eaau6562 (2019-06-18)
Most achievements to engineer blood vessels are based on multiple-step manipulations such as manual sheet rolling or sequential cell seeding followed by scaffold degradation. Here, we propose a one-step strategy using a microfluidic coextrusion device to produce mature functional blood...
Fernando P Conte et al.
Molecules (Basel, Switzerland), 20(2), 2636-2657 (2015-02-06)
Gedunin, a natural limonoid from Meliaceae species, has been previously described as an antiinflammatory compound in experimental models of allergic inflammation. Here, we report the antiinflammatory and antinociceptive effects of gedunin in an acute model of articular inflammation induced by...
Walid Semaan et al.
Biochemical pharmacology, 94(2), 91-100 (2015-02-11)
Important structural differences imply that human and mouse mast cell chymases may differ with respect to their enzymatic properties. We compared in this study the catalytic efficiencies of recombinant human chymase (rCMA1) and its functional murine homologue recombinant mouse mast...
Nicole S Olgun et al.
Toxicology and applied pharmacology, 282(3), 275-284 (2014-09-18)
Preterm birth (PTB), defined as any delivery occurring prior to the completion of 37 weeks' gestation, currently accounts for 11-12% of all births in the United States. Maternal genito-urinary infections account for up to 40% of all PTBS and induce...
Sydney Correia Leão et al.
Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular, 30(2), 211-218 (2015-06-25)
Rheumatic Fever represents a serious public health problem in developing countries, with thousands of new cases each year. It is an autoimmune disease, which occurs in response to infection by streptococcus A. The aim of this study was to evaluate...
Cheong-Yong Yun et al.
Theranostics, 9(3), 646-660 (2019-02-28)
Rationale: SOX10 (SRY-related HMG-box 10) and MITF-M (microphthalmia-associated transcription factor M) restrict the expression of melanogenic genes, such as TYR (tyrosinase), in melanocytes. DACE (diacetylcaffeic acid cyclohexyl ester) inhibits melanin production in α-MSH (α-melanocyte stimulating hormone)-activated B16-F0 melanoma cells. In...
Takayuki Matsumoto et al.
Life sciences, 118(2), 200-205 (2013-12-03)
There is a growing body of evidence suggesting that epigallocatechin gallate (EGCG), a major catechin isolated from green tea, has several beneficial effects, such as anti-oxidant and anti-inflammatory activities. However, whether treatment with EGCG can suppress the endothelin-1 (ET-1)-induced contraction...
Jula K Inrig et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 65(3), 464-473 (2014-12-23)
Intradialytic hypertension affects ∼15% of hemodialysis patients and is associated with increased morbidity and mortality. While intradialytic hypertension is associated with increases in endothelin 1 relative to nitric oxide (NO), the cause of these imbalances is unknown. In vitro evidence suggests...
S Civelek et al.
Journal of clinical laboratory analysis, 29(3), 184-190 (2014-05-07)
Metabolic syndrome (MetS) defines a well-known cluster of metabolic disturbances associated with an increased risk of cardiovascular disease and diabetes. The aim of this study was to examine the distribution of soluble lectin-like oxidized low-density lipoprotein (LDL) receptor-1 (sLOX-1) levels...
María V Correa et al.
Pflugers Archiv : European journal of physiology, 466(9), 1819-1830 (2013-12-12)
Emerging evidence supports a key role for endothelin-1 (ET-1) and the transactivation of the epidermal growth factor receptor (EGFR) in angiotensin II (Ang II) action. We aim to determine the potential role played by endogenous ET-1, EGFR transactivation and redox-dependent...
Zachary Barrett-O'Keefe et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 70(5), 554-565 (2014-05-14)
The endothelin-1 vasoconstrictor pathway contributes to age-related elevations in resting peripheral vascular tone primarily through activation of the endothelin subtype A (ET(A)) receptor. However, the regulatory influence of ET(A)-mediated vasoconstriction during exercise in the elderly is unknown. Thus, in 17...
Francesca Schinzari et al.
American journal of physiology. Endocrinology and metabolism, 309(9), E787-E792 (2015-09-17)
Patients with metabolically healthy obesity (MHO) do not present the cluster of metabolic abnormalities that define the metabolic syndrome (MetS). Whether MHO is associated with lower impairment of vasoreactivity than the MetS is unknown. For this purpose, forearm blood flow...
Vijaywant Brar et al.
PloS one, 10(3), e0121810-e0121810 (2015-03-26)
Healthy middle-aged postmenopausal women have higher endothelium-dependent dilation and lower vasoconstrictor activity of endothelin-1 than men. Whether these sex-specific differences extend to patients with cardiovascular risk factors has not been investigated. The current study aimed to determine whether, in patients...
G Oczkowicz et al.
Transplantation proceedings, 46(8), 2542-2544 (2014-11-09)
The aim of this paper was to describe differences between levels of endothelial nitric oxide synthase (NOS-3) and endothelin-1 (ET-1) in swine kidneys removed from living donors (group I) and after inducing brain death by brain herniation (group II) and...
Yan-Jie Lin et al.
Biochemical and biophysical research communications, 460(3), 497-503 (2015-04-01)
Endothelin-1 (ET-1) is known as potent vasoconstrictor, by virtue of its mitogenic effects, and may deteriorate the process of hypertension and atherosclerosis by aggravating hyperplasia and migration in VSMCs. Our previous study demonstrated that insulin infusion caused sequential induction of...
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