Showing 1-30 of 32 résultats for "MABN328"
Bergljót Magnadóttir et al.
International journal of molecular sciences, 22(2) (2021-01-21)
Extracellular vesicles (EVs) are lipid bilayer vesicles which are released from cells and play multifaceted roles in cellular communication in health and disease. EVs can be isolated from various body fluids, including serum and plasma, and are usable biomarkers as...
J L Walker et al.
Molecular biology of the cell, 29(13), 1555-1570 (2018-05-03)
Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring. The signals underlying these differing pathways are complex and incompletely...
Marianne Engström et al.
Journal of translational medicine, 16(1), 214-214 (2018-08-02)
A relationship between rheumatoid arthritis (RA) and periodontitis has been suggested from findings that individuals with RA are prone to have advanced periodontitis and vice versa. In search of possible common pathogenetic features of these two diseases, we investigated the...
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Michael F Criscitiello et al.
Frontiers in immunology, 11, 651-651 (2020-05-16)
Alligators are crocodilians and among few species that endured the Cretaceous-Paleogene extinction event. With long life spans, low metabolic rates, unusual immunological characteristics, including strong antibacterial and antiviral ability, and cancer resistance, crocodilians may hold information for molecular pathways underlying...
Pinar Uysal-Onganer et al.
International journal of molecular sciences, 21(4) (2020-02-27)
Glioblastoma multiforme (GBM) is an aggressive adult brain tumour with poor prognosis. Roles for peptidylarginine deiminases (PADs) in GBM have recently been highlighted. Here, two GBM cell lines were treated with PAD2, PAD3 and PAD4 isozyme-specific inhibitors. Effects were assessed...
Bergljót Magnadóttir et al.
Comparative biochemistry and physiology. Part D, Genomics & proteomics, 34, 100676-100676 (2020-03-03)
Peptidylarginine deiminases (PADs) are a family of phylogenetically conserved calcium-dependent enzymes which cause post-translational protein deimination. This can result in neoepitope generation, affect gene regulation and allow for protein moonlighting via functional and structural changes in target proteins. Extracellular vesicles...
Dong Hyun Sohn et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(11), 2877-2887 (2015-08-01)
Anti-citrullinated protein antibodies (ACPAs) are characteristic of rheumatoid arthritis (RA). However, their presence years before the onset of clinical RA is perplexing. Although multiple putative citrullinated antigens have been identified, no studies have demonstrated the specific capacity of these antigens...
Indira Neeli et al.
Frontiers in immunology, 7, 528-528 (2016-12-10)
Studies on NETosis demand reliable and convenient markers to monitor the progress of this form of cell death. Because a determining step in the release of nuclear chromatin NETs requires the conversion of arginine residues to citrulline residues in histones...
Jill A Poole et al.
Respiratory research, 18(1), 214-214 (2017-12-24)
Agriculture organic dust exposures induce lung disease with lymphoid aggregates comprised of both T and B cells. The precise role of B cells in mediating lung inflammation is unknown, yet might be relevant given the emerging role of B cells...
Preparation of a monoclonal antibody to citrullinated epitopes: its characterization and some applications to immunohistochemistry in human brain.
Nicholas, Anthony P and Whitaker, John N
Glia, 37, 328-336 (2002)
Robby Engelmann et al.
PloS one, 11(6), e0158773-e0158773 (2016-07-01)
To assess the prerequisites for negative selection of peptidylcitrulline-specific T cells in the thymus. In detail, we here analyzed murine medullary thymic epithelial cells for the expression of peptidylarginine deiminases (PAD) and subsequent citrullination. Medullary thymic epithelial cells were sorted...
John W Wizeman et al.
Molecular vision, 22, 1137-1155 (2016-10-06)
A hallmark of retinal gliosis is the increased detection and modification of the type III intermediate filament (IF) proteins vimentin and glial fibrillary acidic protein (GFAP). Here, we investigated vimentin and GFAP in Müller glia in a mouse model of...
Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.
Stefanelli, et al.
Matrix Biology, 82, 86-104 (2021)
Víctor Casanova et al.
Frontiers in immunology, 11, 85-85 (2020-03-03)
Human rhinoviruses (HRV) are the most common cause of viral respiratory tract infections. While normally mild and self-limiting in healthy adults, HRV infections are associated with bronchiolitis in infants, pneumonia in immunocompromised patients, and exacerbations of asthma and COPD. The...
Timothy J Bowden et al.
Developmental and comparative immunology, 110, 103714-103714 (2020-04-27)
The horseshoe crab is a living fossil and a species of marine arthropod with unusual immune system properties which are also exploited commercially. Given its ancient status dating to the Ordovician period (450 million years ago), its standing in phylogeny...
R Bright et al.
Journal of periodontal research, 53(1), 139-143 (2017-10-19)
Postranslational modification of proteins can lead to the production of autoantibodies and loss of immune tolerance. This process has been hypothesised to be a critical factor in the pathogenesis of rheumatoid arthritis. The objective of this study was to demonstrate...
Michael F Criscitiello et al.
International journal of molecular sciences, 21(8) (2020-04-25)
The bovine immune system is known for its unusual traits relating to immunoglobulin and antiviral responses. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that cause post-translational deimination, contributing to protein moonlighting in health and disease. PADs also regulate extracellular vesicle...
Reduced IgG titers against pertussis in rheumatoid arthritis: Evidence for a citrulline-biased immune response and medication effects.
Holmes, et al.
PLoS ONE, 14, e0217221-e0217221 (2021)
Richard A Phillips et al.
Biology, 9(1) (2020-01-16)
Pelagic seabirds are amongst the most threatened of all avian groups. They face a range of immunological challenges which seem destined to increase due to environmental changes in their breeding and foraging habitats, affecting prey resources and exposure to pollution...
Marco Sancandi et al.
International journal of molecular sciences, 21(8) (2020-04-25)
The identification of biomarkers for early diagnosis of Parkinson's disease (PD) is of pivotal importance for improving approaches for clinical intervention. The use of translatable animal models of pre-motor PD therefore offers optimal opportunities for novel biomarker discovery in vivo....
Sanna Turunen et al.
Arthritis research & therapy, 18(1), 239-239 (2016-10-22)
Seropositive rheumatoid arthritis (RA) is characterized by autoantibodies binding to citrullinated and homocitrullinated proteins. We wanted to study the expression patterns of these disease-associated protein forms and if the rheumatoid nodule and synovial tissue itself contain biologically active levels of...
Expression of citrullinated proteins in murine experimental autoimmune encephalomyelitis.
Nicholas, Anthony P, et al.
The Journal of Comparative Neurology, 486, 254-266 (2005)
Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra.
Nicholas, Anthony P
Neuroscience Letters, 495, 26-29 (2011)
Bergljót Magnadóttir et al.
Biochimie, 171-172, 79-90 (2020-02-28)
Peptidylarginine deiminases (PADs) are phylogenetically conserved calcium-dependent enzymes which post-translationally convert arginine into citrulline in target proteins in an irreversible manner, leading to functional and structural changes in target proteins. Protein deimination can cause the generation of neo-epitopes, affect gene...
Peter J Attilio et al.
Oxidative medicine and cellular longevity, 2017, 8398072-8398072 (2017-06-20)
Oxidative stress and calcium excitotoxicity are hallmarks of traumatic brain injury (TBI). While these early disruptions may be corrected over a relatively short period of time, long-lasting consequences of TBI including impaired cognition and mood imbalances can persist for years...
Andrew V Caprariello et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5528-5533 (2018-05-08)
Although immune attack against central nervous system (CNS) myelin is a central feature of multiple sclerosis (MS), its root cause is unresolved. In this report, we provide direct evidence that subtle biochemical modifications to brain myelin elicit pathological immune responses...
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Michael F Criscitiello et al.
Molecular immunology, 117, 37-53 (2019-11-17)
Peptidylarginine deiminases (PADs) are phylogenetically conserved calcium-dependent enzymes which post-translationally convert arginine into citrulline in target proteins in an irreversible manner, causing functional and structural changes in target proteins. Protein deimination causes generation of neo-epitopes, affects gene regulation and also...
Meike Wiese et al.
Epigenetics & chromatin, 12(1), 21-21 (2019-04-04)
Stem cell differentiation involves major chromatin reorganisation, heterochromatin formation and genomic relocalisation of structural proteins, including heterochromatin protein 1 gamma (HP1γ). As the principal reader of the repressive histone marks H3K9me2/3, HP1 plays a key role in numerous processes including...

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