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Targeting the IRE1α?XBP1 branch of the unfolded protein response in human diseases.
Jiang D, et al.
Seminars in Cancer Biology, 33, 48-56 (2015)
Jirka Peschek et al.
EMBO reports, 16(12), 1688-1698 (2015-10-21)
The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER). Upon sensing protein folding perturbations in the ER...
Vladislav Pokatayev et al.
Nature immunology, 21(2), 158-167 (2020-01-15)
STING (stimulator of interferon genes) is an important innate immune protein, but its homeostatic regulation at the resting state is unknown. Here, we identified TOLLIP as a stabilizer of STING through direct interaction to prevent its degradation. Tollip deficiency results...
Baoyi Zhu et al.
Journal of cellular physiology, 235(10), 7370-7382 (2020-02-11)
Smooth muscle cells (SMCs) are characterized by a high degree of phenotypic plasticity. Contractile differentiation is governed by myocardin-related transcription factors (MRTFs), in particular myocardin (MYOCD), and when their drive is lost, the cells become proliferative and synthetic with an...
4μ8C inhibits insulin secretion independent of IRE1α RNase activity.
Sato H, et al.
Cell Structure and Function, 42(1), 61-70 (2017)
Manuel Garcia-Moreno et al.
Molecular cell, 74(1), 196-211 (2019-02-26)
The compendium of RNA-binding proteins (RBPs) has been greatly expanded by the development of RNA-interactome capture (RIC). However, it remained unknown if the complement of RBPs changes in response to environmental perturbations and whether these rearrangements are important. To answer these...
Maria Saveria Gilardini Montani et al.
British journal of cancer, 123(2), 298-306 (2020-05-19)
Kaposi's Sarcoma Herpesvirus (KSHV) is a gammaherpesvirus strongly linked to human cancer. The virus is also able to induce immune suppression, effect that contributes to onset/progression of the viral-associated malignancies. As KSHV may infect macrophages and these cells abundantly infiltrate...