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Chemically Defined Media Supplements Improve Quality and Lower Risk in Upstream Bioprocessing

Chemically defined media supplements offer many benefits including decreased lot-to-lot variation, decreased risks, and improved glycosylation profiles.

Software Simplifies Compliance with 21 CFR Part 11 and EudraLex Good Manufacturing Practice Volume 4 Annex 11

How software can simplify 21 CFR Part 11 and EudraLex Volume 4 Annex 11 compliance and provide additional benefits such as access control, audit trails and easier search and retrieval.

Synthetic Carbon Adsorbents for Host Cell Protein Removal in Monoclonal Antibody Purification

Demonstration of the excellent capability of Carboxen® synthetic carbon adsorbents to reduce host cell proteins (HCPs) and recover monoclonal antibodies (mAbs) using a post protein A pool step.

Value Drivers and Benefits of Closed Processing

Closed processing enables more streamlined, flexible, and cost-effective multi-product and multi-modal facilities, while ensuring the highest level of product quality and safety. Learn more about how contamination risk is mitigated and the additional value and benefits of closed processing.

One-Batch Calibration: A Process-, Instrument-, Scale- & Site-agnostic Method For Streamlining Raman Implementation

Challenges associated with Raman spectroscopy implementation in bioprocesses can be overcome by the innovative one-batch calibration approach. This streamlined process requires less time and resources compared to traditional approaches, unlocking Raman benefits for biopharmaceutical applications.

Cell Harvest, Lysis, Neutralization and Clarification of Plasmid DNA (pDNA) for mRNA, plasmid-based DNA Vaccines, and Viral Vector applications

An overview of the cell harvest, lysis, neutralization, and clarification steps used for pDNA purification along with case study and practical advice.

Chromatographic Purification of Plasmid DNA (pDNA) for mRNA, Plasmid-based DNA Vaccines, and Viral Vector Applications

See case study examples of how to optimize chromatographic purification of plasmid DNA for Biopharmaceutical Applications.

Plasmid DNA Purification Process

Free eBook outlines plasmid DNA manufacturing process and downstream purification challenges for various applications.

Performance Characteristics of the Mobius^® ADC Reactor for Conjugation

ADC production relies on conjugation to link the cytotoxic payload to the mAb. Explore the benefits of a single-use reactor for efficient conjugation.

Improving Efficiency and Control in Biopharma Manufacturing With Process Analytical Technology

Key considerations for process analytical technology (PAT) implementation in biopharma and its role in enabling the facility of the future.

Assay of Betamethasone Sodium Phosphate by HPTLC

Development of an HPTLC based method, using Silica Gel 60 F254 plate, to determine Betamethasone Sodium Phosphate over a concentration range of 1 to 7 µg/spot.

Assay of Doxepin Hydrochloride USP Monograph

The FPP Purospher® STAR RP-8e column offers a reliable and consistent assay with strong peak shapes and linearity, ensuring precise quantification.

Clozapine Assay HPLC Method acc to USP Monograph

An HPLC-UV method for the identification and quantification of clozapine in API samples and tablet formulations, following the USP monograph guidelines.

Determination of Baicalin, Chlorogenic acid and Forsythin

Analyze Shuanghuang Lian oral liquid using Discovery® HS C18 HPLC column per Chinese Pharmacopeia 2020. Quantify baicalin, chlorogenic acid, and forsythin with high accuracy.

API Solubility and Dissolution Enhancement Via Formulation

Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.

Active Pharmaceutical Ingredient (API) Stability in Solid Dose Formulation

This article describes the use of excipients to help address API stability issues.

Improving API Solubility with Mesoporous Silica

Discover how mesoporous silica enhances API solubility, unlocking the full potential of promising drugs with improved bioavailability.

Egg-based and Cell-based Influenza Vaccine Manufacturing Methods

Influenza vaccines are commonly made using egg-based and cell-based manufacturing strategies. Find step-by-step information on the manufacturing process for each method.

Eshmuno^® Fit Custom Affinity Resin Development Services: Frequently Asked Questions

This page answers all the frequently asked questions related to our Eshmuno® Fit custom affinity resin development services.

Antibody Standard Validation

Explore antibody validation, including antibody and target, species validation, lot validation, application validation, storage and handling, citations, and quality control, in detail.

An Introduction to Antibodies: Antigens, Epitopes and Antibodies

Antibodies combine with specific antigens to generate an exclusive antibody-antigen complex. Learn about the nature of this bond and its use as a molecular tag for research.

Protein Conformation Array Multiplexing

Monoclonal antibodies (mAbs) lead biologics growth, predicted $125 billion worldwide sales by 2020, emphasizing their therapeutic significance.

A Highly Sensitive IFN-γ ELISpot Assay to Quantify Cellular Immune Responses to Previous Viral Infection

This study presents an example of a typical ELISpot assay for quantifying the number of pre-existing, antigen-reactive T cells from peripheral blood mononuclear cell (PBMC) samples obtained from donors previously infected with cytomegalovirus (CMV).

Enzymes for Alternative Energy

Explore the hurdles in unlocking glucose energy from lignocellulosic biomass, surpassing challenges compared to starch.

Neuropeptidases

We offers many products related to neuropeptidases for your research needs.

Phosphodiesterases

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and/or cGMP. There are 11 different mammalian PDE families.

Phospholipase C

Phospholipase C hydrolysis of PIP2 regulates cell functions, crucial in extracellular signaling pathway regulation.

Phospholipase D

PLD enzymes catalyze PC hydrolysis, influencing substrate recognition and lipid metabolism.

Tips for Immunofluorescence Protocols

Immunofluorescence uses antibody-conjugated fluorescent molecules for protein localization, modification confirmation, and protein complex visualization.

Multicolor Flow Cytometry | Tips for Building Flow Cytometry Panels

Uncover tips for multicolor flow cytometry experiments, including the challenges in multicolor flow cytometry, steps for how to build a multicolor flow cytometry panel, tandem dyes, and tools for multicolor assay design.

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