438210

LSF Inhibitor, FQI1

The LSF Inhibitor, FQI1 controls the biological activity of LSF.

• Synonym(s): LSF Inhibitor, FQI1, (±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic
• Empirical Formula (Hill Notation): C₁₈H₁₇NO₄
• Molecular Weight: 311.33
• UNSPSC Code: 12352200
• NACRES: NA.28
• MDL number: MFCD03632583

Properties

• Product Name: LSF Inhibitor, FQI1, The LSF Inhibitor, FQI1 controls the biological activity of LSF.
• SMILES string: N1c2c(cc4c(c2)OCO4)C(CC1=O)c3c(cccc3)OCC
• InChI: 1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20)
• InChI key: YKSYGLXHLSPWLB-UHFFFAOYSA-N
• assay: >92% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 100 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• Quality Level: 100

Description

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC₅₀ = 2.1 µM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI₅₀ = 3.8, 0.79, and 6.3 µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).

Other Notes

Grant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA109, 4503.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3