Merck
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CH2900018

SAFC

Calcium Levofolinate Hydrate / Levoleucovorin Calcium Pentahydrate

Ph. Eur.

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Synonym(s):
L-Calcium Folinate, L-Leucovorin Calcium, Levofolinate Calcium Hydrate, Levoleucovorin Calcium

biological source

synthetic

Quality Level

600

grade

GMO free
GMP
Halal
Kosher

Agency

Ph. Eur.
USP

form

powder

application(s)

liquid formulation
pharmaceutical
solid formulation

storage temp.

2-8°C

Related Categories

General description

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Calcium Levofolinate Hydrate has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.

Packaging

Customized packaging possible

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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