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R7649

(−)-Riboflavin

meets USP testing specifications

Synonym(s):

Lactoflavin, Vitamin B2, Vitamin G

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Size/SKUAvailabilityPrice
25 g
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£65.60
100 g
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£214.00
500 g
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£816.00
1 kg
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£1,250.00

About This Item

Empirical Formula (Hill Notation):
C17H20N4O6
CAS Number:
83-88-5
Molecular Weight:
376.36
NACRES:
NA.21
PubChem Substance ID:
24899397
eCl@ss:
34058005
UNSPSC Code:
12352205
EC Number:
201-507-1
MDL number:
MFCD00005022
Beilstein/REAXYS Number:
97825

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Quality Segment

200

agency

USP/NF, meets USP testing specifications

assay

98.0-102.0% dry basis

form

powder

color

dark yellow

mp

290 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1

InChI

1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1

InChI key

AUNGANRZJHBGPY-SCRDCRAPSA-N

General description

Riboflavin is an essential vitamin soluble in water. Milk and eggs are found to be its major sources. Riboflavin is usually bound to enzymes in all tissues. During riboflavin localization in plasma, it is bound to albumin and specific immunoglobulins.

Application

(-)-Riboflavin has been used to study its antimicrobial effect in vitro, through ultraviolet light A (UVA) activation.It has also been used collagen coated surface of the polyethylene membrane for cross-linking astrocytes.

Biochem/physiol Actions

Riboflavin serves as a precursor for the active enzyme cofactors riboflavin 5′-monophosphate (also called flavin mononucleotide or FMN) and flavin adenine dinucleotide (FAD). Riboflavin deficiency in the diet results in a well-defined syndrome known as ariboflavinosis, Riboflavin exhibits protective effects against tumor development and cardiovascular disease. Its deficiency often affects metabolism involving redox reactions. Riboflavin is found essential for iron absorption, gastrointestinal development, neurogenesis, corneal vascularization and corneal opacity.

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This Item
R06000001603006R4500
(−)-Riboflavin meets USP testing specifications

Sigma-Aldrich

R7649

(−)-Riboflavin

Riboflavin European Pharmacopoeia (EP) Reference Standard

R0600000

Riboflavin

Riboflavin United States Pharmacopeia (USP) Reference Standard

USP

1603006

Riboflavin

(−)-Riboflavin from Eremothecium ashbyii, ≥98%

Sigma-Aldrich

R4500

(−)-Riboflavin

description

meets USP testing specifications

description

European Pharmacopoeia (EP) Reference Standard

description

United States Pharmacopeia (USP) Reference Standard

description

from Eremothecium ashbyii, ≥98%

assay

98.0-102.0% dry basis

assay

-

assay

-

assay

≥98%

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

form

powder

form

solid

form

-

form

powder

mp

290 °C (dec.) (lit.)

mp

290 °C (dec.) (lit.)

mp

290 °C (dec.) (lit.)

mp

290 °C (dec.) (lit.)

color

dark yellow

color

-

color

-

color

yellow to orange

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

200

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

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Questions

1–4 of 4 Questions  

  1. Gentilissimi, mi occorre uno standard per la riboflavina in HPLC con cosegna rapida, il prodotto con il codice R7649 può essere usato come standard in HPLC?Se non si può mi consigliate un prodotto?

    1 answer

    1. This product is not intended for use as an analytical standard. Please see the link below to review the Certified Reference Material, PHR1053. This material is tested against and traceable to the current USP standard. Testing includes High-Performance Liquid Chromatography (HPLC):
      https://www.sigmaaldrich.com/product/sial/phr1054

      Please see the following link to review a sample or lot-specific Certificate of Analysis, which includes the Chromatogram:
      https://www.sigmaaldrich.com/product/sial/phr1054#product-documentation

      Helpful?

  2. Is this of animal origin

    1 answer

    1. This product is typically not animal derived. However, the source of this material may change from lot to lot and is reported on the Certificate of Origin. To check the source of a current lot, we kindly ask you to navigate to the link-https://www.sigmaaldrich.com/techservice, click on "Product Documentation" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.

      Helpful?

  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  4. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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