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A2504

Sigma-Aldrich

6-Aminocaproic acid

≥99% (titration), powder

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Synonym(s):
ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
Linear Formula:
H2N(CH2)5CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein:
906872
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic

Quality Level

Assay

≥99% (titration)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white

mp

207-209 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

SMILES string

NCCCCCC(O)=O

InChI

1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)

InChI key

SLXKOJJOQWFEFD-UHFFFAOYSA-N

Gene Information

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1 of 4

This Item
8.00145PHR1224A7824
6-Aminocaproic acid ≥99% (titration), powder

Sigma-Aldrich

A2504

6-Aminocaproic acid

6-Aminohexanoic acid for synthesis

Sigma-Aldrich

8.00145

6-Aminohexanoic acid

Aminocaproic acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1224

Aminocaproic acid

6-Aminocaproic acid BioUltra, ≥99%

Sigma-Aldrich

A7824

6-Aminocaproic acid

form

powder

form

crystals

form

-

form

powder

mp

207-209 °C (dec.) (lit.)

mp

205 °C

mp

207-209 °C (dec.) (lit.)

mp

207-209 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

solubility

587.55 g/L

solubility

-

solubility

H2O: 0.5 M, clear, colorless

Quality Level

300

Quality Level

200

Quality Level

300

Quality Level

300

biological source

synthetic

biological source

-

biological source

-

biological source

synthetic (organic)

Application

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

Biochem/physiol Actions

EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carbo­xy­peptidase, plasmin, and plasminogen activator.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

404.6 - 408.2 °F

Flash Point(C)

207 - 209 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Engineered three-dimensional models of neuromuscular tissues are promising for use in mimicking their disorder states in vitro. Although several models have been developed, it is still challenging to mimic the physically separated structures of motor neurons (MNs) and skeletal muscle
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To estimate the relative risks of death, myocardial infarction, stroke, and renal failure or dysfunction between antifibrinolytics and no treatment following the suspension of aprotinin from the market in 2008 for safety reasons and its recent reintroduction in Europe and
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E M Van Hoeyveld et al.
The Journal of allergy and clinical immunology, 76(4), 543-550 (1985-10-01)
The effect of epsilon-aminocaproic acid (EACA) on the degradation of an aqueous Lolium perenne extract was studied by intracutaneous tests and by RAST inhibition. Extracts for skin testing stored at 4 degrees C for 12 months and at 37 degrees
Ai Kia Yip et al.
Biophysical journal, 104(1), 19-29 (2013-01-22)
Cells sense the rigidity of their substrate; however, little is known about the physical variables that determine their response to this rigidity. Here, we report traction stress measurements carried out using fibroblasts on polyacrylamide gels with Young's moduli ranging from

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