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H3631

Sigma-Aldrich

Hyaluronidase from bovine testes

Type VI-S, lyophilized powder, 3,000-15,000 units/mg solid

Synonym(s):
Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase
CAS Number:
Enzyme Commission number:
EC Number:
MDL number:
NACRES:
NA.54

biological source

bovine testis

Quality Level

type

Type VI-S

form

lyophilized powder

specific activity

3,000-15,000 units/mg solid

mol wt

~55 kDa (four subunits of 14 kDa each)

UniProt accession no.

relevant disease(s)

cancer

storage temp.

−20°C

Gene Information

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Packaging

3000, 15000, 30000 units in glass bottle

Biochem/physiol Actions

Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression.
These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.

Unit Definition

One unit will cause a change in % transmittance at 600 nm of 0.330 per minute at pH 5.35 at 37 °C in a 2.0 mL reaction mixture (45 minute assay).

Preparation Note

Chromatographically purified

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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