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H3884

Sigma-Aldrich

Hyaluronidase from bovine testes

Type IV-S, lyophilized powder (essentially salt-free), 750-3000 units/mg solid

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Synonym(s):
Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase
CAS Number:
Enzyme Commission number:
EC Number:
MDL number:

biological source

bovine testis

Quality Level

conjugate

conjugate (Glucosaminoglycan)

type

Type IV-S

form

lyophilized powder (essentially salt-free)

specific activity

750-3000 units/mg solid

mol wt

~55 kDa (four subunits of 14 kDa each)

UniProt accession no.

application(s)

diagnostic assay manufacturing

relevant disease(s)

cancer

storage temp.

−20°C

Gene Information

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This Item
H3506H6254H3631
Hyaluronidase from bovine testes Type IV-S, lyophilized powder (essentially salt-free), 750-3000 units/mg solid

H3884

Hyaluronidase from bovine testes

Hyaluronidase from bovine testes Type I-S, lyophilized powder, 400-1000 units/mg solid

H3506

Hyaluronidase from bovine testes

Hyaluronidase from sheep testes Type V, lyophilized powder, ≥1,500 units/mg solid

H6254

Hyaluronidase from sheep testes

Hyaluronidase from bovine testes Type VI-S, lyophilized powder, 3,000-15,000 units/mg solid

H3631

Hyaluronidase from bovine testes

specific activity

750-3000 units/mg solid

specific activity

400-1000 units/mg solid

specific activity

≥1,500 units/mg solid

specific activity

3,000-15,000 units/mg solid

Gene Information

cow ... HYAL1(515397), HYAL2(281838)

Gene Information

-

Gene Information

-

Gene Information

cow ... HYAL1(515397), HYAL2(281838)

application(s)

diagnostic assay manufacturing

application(s)

diagnostic assay manufacturing

application(s)

diagnostic assay manufacturing

application(s)

-

form

lyophilized powder (essentially salt-free)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

mol wt

~55 kDa (four subunits of 14 kDa each)

mol wt

~55 kDa (four subunits of 14 kDa each)

mol wt

55 kDa

mol wt

~55 kDa (four subunits of 14 kDa each)

Biochem/physiol Actions

Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression.
These enzymes randomly cleave β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.

Unit Definition

One unit will degrade 0.75 μg of the polysaccharide hyaluronic acid per minute at pH 5.35 at 37 ºC (as measured by turbidimetric absorbance (λ: 600nm) when complexed with BSA after 45 minutes).

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Resp. Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Articles

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

Protocols

To measure hyaluronidase activity, a turbidimetric determination assay is used at 600 nm. One unit of hyaluronidase activity will cause a change in absorbance of 0.330 per minute at pH 5.35 at 37 °C.

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