The solution stability of this product at -80°C has not been investigated. Stock solutions prepared in ethanol are stable up to 6 months, when stored -20 deg C in the dark. Further stability studies have not been performed. Note that the Certified Reference Material, Product P-069, a 1 mg/mL solution of Progesterone in Acetonitrile, is stored at -20°C and assigned a shelf life of approximately 5 years.
P8783
Progesterone
powder, BioReagent, suitable for cell culture
Synonym(s):
4-Pregnene-3,20-dione
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1 G
£31.30
5 G
£97.70
25 G
£210.00
About This Item
Empirical Formula (Hill Notation):
C21H30O2
CAS Number:
Molecular Weight:
314.46
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-350-6
Beilstein/REAXYS Number:
1915950
MDL number:
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥99%
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InChI key
RJKFOVLPORLFTN-LEKSSAKUSA-N
InChI
1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
SMILES string
CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
biological source
synthetic (organic)
description
synthesized from materials derived from plant source
product line
BioReagent
assay
≥99%
form
powder
potency
0.1-20 ng/mL
technique(s)
cell culture | mammalian: suitable
Quality Level
Gene Information
human ... ABCB1(5243), AR(367), CYP2C9(1559), EBP(10682), ESR1(2099), ESR2(2100), NR3C1(2908), NR3C2(4306), PGR(5241), SERPINA6(866)
mouse ... Esr1(13982)
rat ... Ar(24208), Nr3c1(24413), Pgr(25154)
storage temp.
room temp
mp
128-132 °C (lit.)
solubility
absolute ethanol: 1 mg/mL
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1 of 4
This Item | |||
|---|---|---|---|
| biological source synthetic (organic) | biological source synthetic (organic) | biological source - | biological source synthetic (organic) |
| assay ≥99% | assay ≥99% | assay ≥97% | assay ≥99% |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| product line BioReagent | product line BioXtra | product line - | product line - |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) - |
| form powder | form powder | form solid | form powder |
General description
Progesterone is a steroid hormone secreted by the ovaries.
Application
Use in cell culture applications to study sterol regulation of cell signaling and gene expression.
Progesterone has been used:
- as a growth-promoting hormone in basal medium for bovine mammary epithelial cell culture
- to test its neuroprotective abilities in a well-characterized lateral cortical contusion injury (CCI) model
- as an endocytosis inhibitor to study its effect on Coxsackievirus A9 infection on A549 cells
Biochem/physiol Actions
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation.
Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer.
Progesterone is a hormone that maintains pregnancy. It is essential for embryo formation, development and survival in almost all mammals. This hormone exhibits its action via progesterone receptor, which is specifically expressed in the endometrial stroma throughout pregnancy. It is known to prevent preterm delivery, when administered intramuscularly. Progesterone also controls gonadotropin secretion, activates sexual behavior and triggers ovarian events leading to ovulation. It stimulates the growth and differentiation of the uterus and prevents uterine contractility.
Physical form
powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Preparation Note
To prepare 20μg/ml stock solution, add 1ml absolute ethanol per mg progesterone, gently swirl to dissolve, add 49ml sterile medium per ml ethanol.
Other Notes
Steroid hormone produced by the corpus luteum.
signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Lact. - Repr. 1A
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Efficacy of progesterone following a moderate unilateral cortical contusion injury
Gilmer LK, et al.
Journal of Neurotrauma, 25(6), 593-602 (2008)
Clinical Reproductive Medicine and Surgery, 84(7), 17-17 (2007)
Peroxisome proliferator-activated receptor-? activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents
A.K.G.Kadegowda, et al.
Journal of Dairy Science, 92, 276-4289 (2009)
Internalization of coxsackievirus A9 is mediated by beta2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin
Heikkila O, et al.
Journal of Virology, 84(7), 3666-3681 (2010)
Neonatal progesterone programs adult uterine responses to progesterone and susceptibility to uterine dysfunction
Dhakal P, et al.
Endocrinology, 156(10), 3791-3803 (2015)
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What is the stability of progesterone reconstituted in ethanol and stored in the -80?
1 answer-
Helpful?
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How can a 10mg/ml stock solution of PHR1142 be prepared for injection into a mouse?
1 answer-
The solubility of Progesterone in water is very low. For in vivo studies, the solubility of PROGESTERONE is 0.02 mg/ml in water and 39 mg/ml in H5784 (45% w/v 2-Hydroxypropyl-β-cyclodextrin). We do not run any in vivo studies with any of our chemicals. To use in animal studies, it is recommended to use the Cell culture tested product and also screen lots. P6149 and P8783 are the cell culture tested product numbers, and PHR1142 is a reference standard.
Helpful?
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What is the appropriate method for reconstituting item P8783, Progesterone?
1 answer-
Progesterone dissolves in DMSO to 100 mM and in ethanol to 100 mM.
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