Merck
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PZ0181

Sigma-Aldrich

PD184352

≥98% (HPLC)

Synonym(s):
2-(2-Chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide, CI-1040
Empirical Formula (Hill Notation):
C17H14ClF2IN2O2
CAS Number:
Molecular Weight:
478.66
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

manufacturer/tradename

Pfizer®

color

white to tan

solubility

DMSO: ≥30 mg/mL

originator

Pfizer

storage temp.

room temp

SMILES string

Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F

InChI

1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)

InChI key

GFMMXOIFOQCCGU-UHFFFAOYSA-N

Gene Information

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PD184352 ≥98% (HPLC)

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Sigma-Aldrich

P4620

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assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

solid

manufacturer/tradename

Pfizer®

manufacturer/tradename

-

manufacturer/tradename

Pfizer®

manufacturer/tradename

-

color

white to tan

color

faint yellow to dark orange

color

white to off-white

color

white to beige

solubility

DMSO: ≥30 mg/mL

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: soluble >10 mg/mL, H2O: insoluble

originator

Pfizer

originator

GlaxoSmithKline

originator

Pfizer

originator

Pfizer

Biochem/physiol Actions

PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

Pictograms

Environment

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Aquatic Acute 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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